NDLI: Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions.

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Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zwerger, Monika Olins, Don E. Jaalouk, Diana E. Olins, Ada L. Weitz, David A. Ung, W. Lloyd Eydelnant, Irwin A. Herrmann, Harald Rowat, Amy C. Lammerding, Jan
Description	Author Affiliation: Rowat AC ( Department of Integrative Biology and Physiology, UCLA, Los Angeles, California 90095, USA. rowat@ucla.edu)
Abstract	Neutrophils are characterized by their distinct nuclear shape, which is thought to facilitate the transit of these cells through pore spaces less than one-fifth of their diameter. We used human promyelocytic leukemia (HL-60) cells as a model system to investigate the effect of nuclear shape in whole cell deformability. We probed neutrophil-differentiated HL-60 cells lacking expression of lamin B receptor, which fail to develop lobulated nuclei during granulopoiesis and present an in vitro model for Pelger-Huët anomaly; despite the circular morphology of their nuclei, the cells passed through micron-scale constrictions on similar timescales as scrambled controls. We then investigated the unique nuclear envelope composition of neutrophil-differentiated HL-60 cells, which may also impact their deformability; although lamin A is typically down-regulated during granulopoiesis, we genetically modified HL-60 cells to generate a subpopulation of cells with well defined levels of ectopic lamin A. The lamin A-overexpressing neutrophil-type cells showed similar functional characteristics as the mock controls, but they had an impaired ability to pass through micron-scale constrictions. Our results suggest that levels of lamin A have a marked effect on the ability of neutrophils to passage through micron-scale constrictions, whereas the unusual multilobed shape of the neutrophil nucleus is less essential.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	12
Volume Number	288
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2013-03-22
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Nuclear Envelope Metabolism Cell Movement Cell Nucleus Physiology Cell Nucleus Shape Gene Expression HL-60 Cells Lamin Type A Biosynthesis Genetics Microfluidic Analytical Techniques Neutrophil Infiltration Neutrophils Receptors, Cytoplasmic And Nuclear Tretinoin Pharmacology Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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