NDLI: 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2013 Volume: 288 Issue: 52

Year: 2013 Volume: 288 Issue: 51

Year: 2013 Volume: 288 Issue: 50

Year: 2013 Volume: 288 Issue: 49

Year: 2013 Volume: 288 Issue: 48

Year: 2013 Volume: 288 Issue: 47

Year: 2013 Volume: 288 Issue: 46

Year: 2013 Volume: 288 Issue: 45

Year: 2013 Volume: 288 Issue: 44

Year: 2013 Volume: 288 Issue: 43

Year: 2013 Volume: 288 Issue: 42

Year: 2013 Volume: 288 Issue: 41

Year: 2013 Volume: 288 Issue: 40

Year: 2013 Volume: 288 Issue: 39

Year: 2013 Volume: 288 Issue: 38

Year: 2013 Volume: 288 Issue: 37

Year: 2013 Volume: 288 Issue: 36

Year: 2013 Volume: 288 Issue: 35

Year: 2013 Volume: 288 Issue: 34

Year: 2013 Volume: 288 Issue: 33

Year: 2013 Volume: 288 Issue: 32

Year: 2013 Volume: 288 Issue: 31

Year: 2013 Volume: 288 Issue: 30

Year: 2013 Volume: 288 Issue: 29

Year: 2013 Volume: 288 Issue: 28

Year: 2013 Volume: 288 Issue: 27

Year: 2013 Volume: 288 Issue: 26

Year: 2013 Volume: 288 Issue: 25

Year: 2013 Volume: 288 Issue: 24

Year: 2013 Volume: 288 Issue: 23

Year: 2013 Volume: 288 Issue: 22

Identification of novel pretranslational regulatory mechanisms for NF-κB activation.

Structure prediction and analysis of DNA transposon and LINE retrotransposon proteins.

Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic $Stimulation^{*♦}$

Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.

Highly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I $Molecule^{*}$

Structure-function analysis of a broad specificity Populus trichocarpa endo-ß-glucanase reveals an evolutionary link between bacterial licheninases and plant XTH gene products.

Integrin-binding Protein Nischarin Interacts with Tumor Suppressor Liver Kinase B1 (LKB1) to Regulate Cell Migration of Breast Epithelial Cells

The Structure of CcmP, a Tandem Bacterial Microcompartment Domain Protein from the β-Carboxysome, Forms a Subcompartment Within a Microcompartment

Putrescine importer PlaP contributes to swarming motility and urothelial cell invasion in Proteus mirabilis.

Structure of the mouse sex peptide pheromone ESP1 reveals a molecular basis for specific binding to the class C G-protein-coupled vomeronasal receptor.

Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals.

Assembly of the Yeast Exoribonuclease Rrp6 with Its Associated Cofactor Rrp47 Occurs in the Nucleus and Is Critical for the Controlled Expression of $Rrp47^{*}$

Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting.

Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2.

Mouse embryonic stem cells are deficient in type I interferon expression in response to viral infections and double-stranded RNA.

Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model.

Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease.

Structure and mechanism of rhomboid protease.

The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance.

Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.

N-terminal and Central Segments of the Type 1 Ryanodine Receptor Mediate Its Interaction with FK506-binding Proteins

Structural basis for a cofactor-dependent oxidation protection and catalysis of cyanobacterial succinic semialdehyde dehydrogenase.

Identification of an Active Site-bound Nitrile Hydratase Intermediate through Single Turnover Stopped-flow Spectroscopy

Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r

NADPH oxidase 4 regulates cardiomyocyte differentiation via redox activation of c-Jun protein and the cis-regulation of GATA-4 gene transcription.

Acidic domain in dentin phosphophoryn facilitates cellular uptake: implications in targeted protein delivery.

Insulin directly regulates steroidogenesis via induction of the orphan nuclear receptor DAX-1 in testicular Leydig cells.

Cysteine proteinase from Streptococcus pyogenes enables evasion of innate immunity via degradation of complement factors.

Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress.

The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar, and tumor growth in vivo.

12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.

An autoinhibited structure of -catenin and its implications for vinculin recruitment to adherens junctions.

The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation.

Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli.

Crystal and solution studies reveal that the transcriptional regulator AcnR of Corynebacterium glutamicum is regulated by citrate-Mg2+ binding to a non-canonical pocket.

G-protein Receptor Kinase 5 Regulates the Cannabinoid Receptor 2-induced Up-regulation of Serotonin 2A Receptors

Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways.

Facilitated Hyperpolarization Signaling in Vascular Smooth Muscle-overexpressing TRIC-A Channels

Structural mechanism of ring-opening reaction of glucose by human serum albumin.

AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae.

Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein.

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

Mutation of light-dependent phosphorylation sites of the Drosophila transient receptor potential-like (TRPL) ion channel affects its subcellular localization and stability.

Diabetes-induced Central Neuritic Dystrophy and Cognitive Deficits Are Associated with the Formation of Oligomeric Reticulon-3 via Oxidative Stress

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity.

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

Ligand-bound thyroid hormone receptor contributes to reprogramming of pancreatic acinar cells into insulin-producing cells.

Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300/CBP-associated factor (PCAF) orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis.

Macro histone variants are critical for the differentiation of human pluripotent cells.

Examining the role of the HIV-1 reverse transcriptase p51 subunit in positioning and hydrolysis of RNA/DNA hybrids.

Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA.

Innate Immunity in Pluripotent Human Cells: ATTENUATED RESPONSE TO INTERFERON-β

Mild electrical stimulation at 0.1-ms pulse width induces p53 protein phosphorylation and G2 arrest in human epithelial cells.

Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis.

The Leucine-rich Pentatricopeptide Repeat-containing Protein (LRPPRC) Does Not Activate Transcription in Mammalian $Mitochondria^{*}$

Positive feedback regulation of human inducible nitric-oxide synthase expression by Ras protein S-nitrosylation.

A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription.

The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin.

Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages.

Structural reevaluation of Streptococcus pneumoniae Lipoteichoic acid and new insights into its immunostimulatory potency.

The Intermediate Conductance Calcium-activated Potassium Channel KCa3.1 Regulates Vascular Smooth Muscle Cell Proliferation via Controlling Calcium-dependent Signaling

Dectin-1 activation controls maturation of ß-1,3-glucan-containing phagosomes.

60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells.

Recruitment of Nox4 to a Plasma Membrane Scaffold Is Required for Localized Reactive Oxygen Species Generation and Sustained Src Activation in Response to Insulin-like Growth Factor-I

HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.

Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.

The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.

Overexpression of USP14 protease reduces I-κB protein levels and increases cytokine release in lung epithelial cells.

Year: 2013 Volume: 288 Issue: 21

Year: 2013 Volume: 288 Issue: 20

Year: 2013 Volume: 288 Issue: 19

Year: 2013 Volume: 288 Issue: 18

Year: 2013 Volume: 288 Issue: 17

Year: 2013 Volume: 288 Issue: 16

Year: 2013 Volume: 288 Issue: 15

Year: 2013 Volume: 288 Issue: 14

Year: 2013 Volume: 288 Issue: 13

Year: 2013 Volume: 288 Issue: 12

Year: 2013 Volume: 288 Issue: 11

Year: 2013 Volume: 288 Issue: 10

Year: 2013 Volume: 288 Issue: 9

Year: 2013 Volume: 288 Issue: 8

Year: 2013 Volume: 288 Issue: 7

Year: 2013 Volume: 288 Issue: 6

Year: 2013 Volume: 288 Issue: 5

Year: 2013 Volume: 288 Issue: 4

Year: 2013 Volume: 288 Issue: 3

Year: 2013 Volume: 288 Issue: 2

Year: 2013 Volume: 288 Issue: 1

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wei, Gang Gao, Yayi Li, Bin Li, Zhiyuan Li, Yangyang Han, Zhijun Yao, Zhengju Gao, Zhimei Lin, Fang Tsun, Andy Wang, Yan
Description	Author Affiliation: Li Y ( Key Laboratory of Molecular Virology and Immunology, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 411 Hefei Road, Shanghai 200025, China.)
Abstract	The abundant expression of IFNÎ³ in Th-inducing POK (ThPOK)-deficient CD4(+) T cells requires the activation of Eomesodermin (Eomes); however, the underlying mechanism of this phenomenon remains unclear. Here we report that ThPOK binds directly to the promoter region of the Eomes gene to repress its expression in CD4(+) T cells. We identified the histone acetyltransferase TIP60 as a co-repressor of ThPOK-target genes, where ectopically expressed TIP60 increased ThPOK protein stability by promoting its acetylation at its Lys(360) residue to then augment the transcriptional repression of Eomes. Moreover, knockdown of endogenous TIP60 abolished the stabilization of ThPOK in CD4(+) T cells, which led to the transcriptional activation of Eomes and increased production of IFNÎ³. Our results reveal a novel pathway by which TIP60 and ThPOK synergistically suppresses Eomes function and IFNÎ³ production, which could contribute to the regulation of inflammation.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	22
Volume Number	288
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2013-05-31
Publisher Place	United States
Access Restriction	Open
Subject Keyword	CD4-Positive T-Lymphocytes Metabolism DNA-Binding Proteins Gene Expression Regulation Immunology Histone Acetyltransferases Repressor Proteins T-Box Domain Proteins Transcription Factors Acetylation Cytology Genetics HEK293 Cells Inflammation Interferon-gamma Biosynthesis Promoter Regions, Genetic Protein Stability Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in