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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ali, Hazrat Vreeken, Rob J. Bovenberg, Roel A. L. Driessen, Arnold J. M. Ries, Marco I. Lankhorst, Peter P. Hankemeier, Thomas |
| Description | Author Affiliation: Ries MI ( From the Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333CC Leiden.) |
| Abstract | Metabolic profiling and structural elucidation of novel secondary metabolites obtained from derived deletion strains of the filamentous fungus Penicillium chrysogenum were used to reassign various previously ascribed synthetase genes of the roquefortine/meleagrin pathway to their corresponding products. Next to the structural characterization of roquefortine F and neoxaline, which are for the first time reported for P. chrysogenum, we identified the novel metabolite roquefortine L, including its degradation products, harboring remarkable chemical structures. Their biosynthesis is discussed, questioning the exclusive role of glandicoline A as key intermediate in the pathway. The results reveal that further enzymes of this pathway are rather unspecific and catalyze more than one reaction, leading to excessive branching in the pathway with meleagrin and neoxaline as end products of two branches. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 52 |
| Volume Number | 288 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2013-12-27 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Fungal Proteins Metabolism Indoles Ligases Penicillium Chrysogenum Genetics Heterocyclic Compounds With 4 Or More Rings Piperazines Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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