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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Muller, Patricia A. J. Caswell, Patrick T. Vousden, Karen H. Trinidad, Antonio G. Norman, Jim C. |
| Description | Author Affiliation: Muller PA ( From the Cancer Research UK Beatson Institute, Glasgow G61 1BD, Scotland, United Kingdom and.) |
| Abstract | The control and processing of microRNAs (miRs) is critical in the regulation of all cellular responses. Previous studies have suggested that a reduction in the expression of certain miRs, or an overall decrease in miR processing through the partial depletion of Dicer, can promote enhanced metastatic potential. We show here that Dicer depletion can promote the invasive behavior of cells that is reflected in enhanced recycling and activation of the growth factor receptors Met and EGF receptor. These responses are also seen in response to the expression of tumor-derived mutant p53s, and we show that mutant p53 can down-regulate Dicer expression through both direct inhibition of the TAp63-mediated transcriptional activation of Dicer and a TAp63-independent control of Dicer protein expression. Our results delineate a clear relationship between mutant p53, TAp63, and Dicer that might contribute to the metastatic function of mutant p53 but, interestingly, also reveal TAp63-independent functions of mutant p53 in controlling Dicer activity. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 1 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-01-03 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DEAD-box RNA Helicases Biosynthesis Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Mutation Neoplasms Metabolism Ribonuclease III Transcription Factors Transcriptional Activation Tumor Suppressor Protein P53 Tumor Suppressor Proteins Cell Line, Tumor Genetics Neoplasm Invasiveness Neoplasm Metastasis Pathology Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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