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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Barbieri, Joseph T. Simon, Nathan C. |
| Description | Author Affiliation: Simon NC ( From the Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.) |
| Abstract | Bacillus cereus is often associated with mild to moderate gastroenteritis; however, some recent isolates cause inhalational anthrax-like diseases and death. These potential emerging human pathogens express multiple virulence factors. B. cereus strain G9241 expresses anthrax toxin, several polysaccharide capsules, and the novel ADP-ribosyltransferase, Certhrax. In this study, we show that Certhrax ADP-ribosylates Arg-433 of vinculin, a protein that coordinates actin cytoskeleton and extracellular matrix interactions. ADP-ribosylation of vinculin disrupted focal adhesion complexes and redistributed vinculin to the cytoplasm. Exogenous vinculin rescued these phenotypes. This provides a mechanism for strain G9241 to breach host barrier defenses and promote bacterial growth and spread. Certhrax is the first bacterial toxin to add a post-translational modification to vinculin to disrupt the actin cytoskeleton. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 15 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-04-11 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | ADP Ribose Transferases Metabolism Bacillus Cereus Bacterial Proteins Focal Adhesions Vinculin Actins Adenosine Diphosphate Ribose Amino Acid Sequence Antigens, Bacterial Bacterial Toxins Cell Adhesion Cytoskeleton Extracellular Matrix HeLa Cells Immunity, Innate Molecular Sequence Data Mutagenesis Phenotype Protein Processing, Post-Translational Recombinant Proteins Sequence Homology, Amino Acid Streptavidin Research Support, N.I.H., Extramural Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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