NDLI: Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.

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Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.

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Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Mi Lei, Cao-qi Shu, Hong-bing Zhang, Yu Hu, Yun-hong Zhong, Bo Xia, Tian
Description	Author Affiliation: Zhang Y ( From the College of Life Sciences, Wuhan University, Wuhan 430072, China.)
Abstract	The transcription factor NF-κB plays a pivotal role in a broad range of physiological and pathological processes, including development, inflammation, and immunity. How NF-κB integrates activating signals to expression of specific sets of target genes is of great interest. Here, we identified Krüppel-like factor 6 (KLF6) as a co-activator of NF-κB after TNF and IL-1ß stimulation. Overexpression of KLF6 enhanced TNF - and IL-1ß-induced activation of NF-κB and transcription of a subset of downstream genes, whereas knockdown of KLF6 had opposite effects. KLF6 interacted with p65 in the nucleus and bound to the promoters of target genes. Upon IL-1ß stimulation, KLF6 was recruited to promoters of a subset of NF-κB target genes in a p65-dependent manner, which was in turn required for the optimal binding of p65 to the target gene promoters. Our findings thus identified KLF6 as a previously unknown but essential co-activator of NF-κB and provided new insight into the molecular regulation of p65-dependent gene expression.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	18
Volume Number	289
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2014-05-02
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Kruppel-Like Transcription Factors Metabolism NF-kappa B Proto-Oncogene Proteins Transcription Factor RelA Transcription, Genetic Active Transport, Cell Nucleus Drug Effects Genetics Apoptosis Blotting, Western Cell Nucleus Gene Expression Regulation HCT116 Cells HEK293 Cells Interleukin-1beta Pharmacology Promoter Regions, Genetic Protein Binding RNA Interference Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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