NDLI: Insulin-like growth factor-2 enhances functions of antigen (Ag)-specific regulatory B cells.

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Insulin-like growth factor-2 enhances functions of antigen (Ag)-specific regulatory B cells.

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Insulin-like growth factor-2 enhances functions of antigen (Ag)-specific regulatory B cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qiu, Shuqi Song, Jiang-ping Li, Meng Liu, Zhigang Liu, Zhi-qiang Geng, Xiao-rui Yang, Ping-chang Yang, Gui
Description	Author Affiliation: Geng XR ( From the Otolaryngology Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen 518060, China, Longgang Central Hospital, ENT Hospital, She); Yang G ( From the Otolaryngology Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen 518060, China, Longgang Central Hospital, ENT Hospital, She); Li M ( From the Otolaryngology Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen 518060, China.); Song JP ( State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.); Liu ZQ ( From the Otolaryngology Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen 518060, China, Longgang Central Hospital, ENT Hospital, She); Qiu S ( From the Otolaryngology Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen 518060, China, Longgang Central Hospital, ENT Hospital, She); Liu Z ( From the Otolaryngology Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen 518060, China.); Yang PC ( From the Otolaryngology Institute of Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine and State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen 518060, China, pcy2356@szu.edu.cn lzg@szu.edu.cn.)
Abstract	Regulatory B cells (Bregs) are important in immune regulation. The factors that regulate Breg functions are less clear. Insulin-like growth factor 2 (IGF2) is capable of inducing hematopoietic stem cell differentiation. This study aimed to investigate the role of IGF2 in the development of Bregs and the enhancement of their function. In this study, the expression of IGF1 receptor (IGF1R) and IGF2R in ovalbumin (OVA)-specific B cells (OVAsBCs) was assessed by real time RT-PCR and Western blotting. The release of interleukin (IL)-10 from OVAsBCs and OVAsBC proliferation were assessed by enzyme-linked immunoassay and proliferation assay. The role of IGF2 in enhancing the function of OVAsBCs was tested with an intestinal allergic inflammation mouse model. The results showed that OVAsBCs expressed high levels of IGF2R. Exposure to both IGF2 and a specific antigen (Ag), OVA, markedly enhanced the expression of IL-10 in OVAsBCs as well as enhanced the IL-10(+) OVAsBC proliferation. The concurrent exposure to IGF2 and specific Ag markedly induced the IL-10 promoter DNA demethylation via activating the STAT5 pathway. IGF2 also enhanced both the OVAsBC proliferation in vivo and the effect of Ag-specific immunotherapy on inhibiting allergic inflammation in the intestine. We conclude that OVAsBCs express high levels of IGF2R and that IGF2 increases the expression of IL-10 in OVAsBCs and enhances OVAsBC proliferation and the inhibitory effect on allergic inflammation.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	25
Volume Number	289
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2014-06-20
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens Immunology B-Lymphocyte Subsets Cell Proliferation Insulin-Like Growth Factor II Animals Genetics Cytology Interleukin-10 Mice Mice, Inbred BALB C Receptor, IGF Type 1 Receptor, IGF Type 2 STAT5 Transcription Factor Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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