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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kihara, Akio Abe, Kensuke Wakashima, Takeshi |
| Description | Author Affiliation: Wakashima T ( From the Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.); Abe K ( From the Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.); Kihara A ( From the Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan kihara@pharm.hokudai.ac.jp.) |
| Abstract | The sphingolipid metabolite sphingosine 1-phosphate (S1P) functions as a lipid mediator and as a key intermediate of the sole sphingolipid to glycerophospholipid metabolic pathway (S1P metabolic pathway). In this pathway, S1P is converted to palmitoyl-CoA through 4 reactions, then incorporated mainly into glycerophospholipids. Although most of the genes responsible for the S1P metabolic pathway have been identified, the gene encoding the trans-2-enoyl-CoA reductase, responsible for the saturation step (conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA) remains unidentified. In the present study, we show that TER is the missing gene in mammals using analyses involving yeast cells, deleting the TER homolog TSC13, and TER-knockdown HeLa cells. TER is known to be involved in the production of very long-chain fatty acids (VLCFAs). A significant proportion of the saturated and monounsaturated VLCFAs are used for sphingolipid synthesis. Therefore, TER is involved in both the production of VLCFAs used in the fatty acid moiety of sphingolipids as well as in the degradation of the sphingosine moiety of sphingolipids via S1P. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 36 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-09-05 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Fatty Acids Metabolism Lysophospholipids Metabolic Networks And Pathways Oxidoreductases Acting On CH-CH Group Donors Sphingosine Analogs & Derivatives Aldehyde-Lyases Genetics Animals Gene Expression Regulation, Enzymologic HeLa Cells Hep G2 Cells Mutation PC12 Cells Phosphotransferases (Alcohol Group Acceptor) RNA Interference Reverse Transcriptase Polymerase Chain Reaction Saccharomyces Cerevisiae Saccharomyces Cerevisiae Proteins Sphingolipids Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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