Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Han, Dong Wook Ko, Kinarm Kim, Sung Min Lim, Kyung Tae Lee, Sung Ho Shin, Chan Young Schöler, Hans R. Lee, Seung Chan Kim, Jong-wan Hyun, Jung Keun Kim, Kee-pyo Hong, Jin Young Ahn, Hong-sun Kim, Jonghun Lee, Hoon Taek Tapia, Natalia |
| Description | Author Affiliation: Hong JY ( From the Department of Nanobiomedical Science and BK21PLUS NBM Global Research Center, Dankook University Graduate School, Cheonan 330714, Republic of Korea, the Institute of Tissue Regeneration Engineering, Dankook University, Cheonan 330714, Republic of Korea.); Lee SH ( the Departments of Stem Cell Biology and.); Lee SC ( the Departments of Stem Cell Biology and.); Kim JW ( From the Department of Nanobiomedical Science and BK21PLUS NBM Global Research Center, Dankook University Graduate School, Cheonan 330714, Republic of Korea, the Institute of Tissue Regeneration Engineering, Dankook University, Cheonan 330714, Republic of Korea.); Kim KP ( the Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.); Kim SM ( the Departments of Stem Cell Biology and.); Tapia N ( the Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.); Lim KT ( the Departments of Stem Cell Biology and.); Kim J ( the Departments of Stem Cell Biology and.); Ahn HS ( From the Department of Nanobiomedical Science and BK21PLUS NBM Global Research Center, Dankook University Graduate School, Cheonan 330714, Republic of Korea, the Institute of Tissue Regeneration Engineering, Dankook University, Cheonan 330714, Republic of Korea.); Ko K ( the Departments of Stem Cell Biology and.); Shin CY ( Pharmacology, School of Medicine, and the Konkuk University Open-Innovation Center, Institute of Biomedical Science & Technology, Konkuk University, Gwangjin-gu, Seoul 143701, Republic of Korea.); Lee HT ( the Departments of Stem Cell Biology and.); Schöler HR ( the Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany, the University of Münster, Medical Faculty, 48149 Münster, Germany, and.); Hyun JK ( From the Department of Nanobiomedical Science and BK21PLUS NBM Global Research Center, Dankook University Graduate School, Cheonan 330714, Republic of Korea, the Institute of Tissue Regeneration Engineering, Dankook University, Cheonan 330714, Republic of Korea, the Department of Rehabilitation Medi); Han DW ( the Departments of Stem Cell Biology and the Konkuk University Open-Innovation Center, Institute of Biomedical Science & Technology, Konkuk University, Gwangjin-gu, Seoul 143701, Republic of Korea, dwhan@konkuk.ac.kr.) |
| Abstract | The spinal cord does not spontaneously regenerate, and treatment that ensures functional recovery after spinal cord injury (SCI) is still not available. Recently, fibroblasts have been directly converted into induced neural stem cells (iNSCs) by the forced expression defined transcription factors. Although directly converted iNSCs have been considered to be a cell source for clinical applications, their therapeutic potential has not yet been investigated. Here we show that iNSCs directly converted from mouse fibroblasts enhance the functional recovery of SCI animals. Engrafted iNSCs could differentiate into all neuronal lineages, including different subtypes of mature neurons. Furthermore, iNSC-derived neurons could form synapses with host neurons, thus enhancing the locomotor function recovery. A time course analysis of iNSC-treated SCI animals revealed that engrafted iNSCs effectively reduced the inflammatory response and apoptosis in the injured area. iNSC transplantation also promoted the active regeneration of the endogenous recipient environment in the absence of tumor formation. Therefore, our data suggest that directly converted iNSCs hold therapeutic potential for treatment of SCI and may thus represent a promising cell source for transplantation therapy in patients with SCI. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 47 |
| Volume Number | 289 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2014-11-21 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Induced Pluripotent Stem Cells Transplantation Neural Stem Cells Spinal Cord Injuries Physiopathology Therapy Animals Cell Differentiation Genetics Physiology Cells, Cultured Embryo, Mammalian Cytology Evoked Potentials, Motor Fibroblasts Metabolism Gene Expression Profiling Immunohistochemistry Mice, Inbred C3H Microscopy, Fluorescence Nerve Regeneration Nestin Oligonucleotide Array Sequence Analysis Rats, Sprague-Dawley Recovery Of Function Reverse Transcriptase Polymerase Chain Reaction SOXB1 Transcription Factors Synapses Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|