NDLI: CXCR4 receptor overexpression in mesenchymal stem cells facilitates treatment of acute lung injury in rats.

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CXCR4 receptor overexpression in mesenchymal stem cells facilitates treatment of acute lung injury in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gao, Peng Yang, Jing-xian Zhang, Nan Wen, Qing-ping Wang, Han-wei Yang, Qing-ping
Description	Author Affiliation: Yang JX ( From the School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.); Zhang N ( From the School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China, School of Pharmacy, China Medical University, Shenyang 110013, China.); Wang HW ( First Affiliated Hospital, Dalian Medical University, Dalian 116011, China, and.); Gao P ( Department of Anesthesiology, Dalian Medical University, Dalian 116044, China.); Yang QP ( From the School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.); Wen QP ( First Affiliated Hospital, Dalian Medical University, Dalian 116011, China, and wenqp050607@gmail.com.)
Abstract	Novel therapeutic regimens for tissue renewal incorporate mesenchymal stem cells (MSCs) as they differentiate into a variety of cell types and are a stem cell type that is easy to harvest and to expand in vitro. However, surface chemokine receptors, such as CXCR4, which are involved in the mobilization of MSCs, are expressed only on the surface of a small proportion of MSCs, and the lack of CXCR4 expression may underlie the low efficiency of homing of MSCs toward tissue damage, which results in a poor curative effect. Here, a rat CXCR4 expressing lentiviral vector was constructed and introduced into MSCs freshly prepared from rat bone marrow. The influence of CXCR4 expression on migration, proliferation, differentiation, and paracrine effects of MSCs was examined in vitro. The in vivo properties of CXCR4-MSCs were also investigated in a model of acute lung injury in rats induced by lipopolysaccharide. Expression of CXCR4 in MSCs significantly enhanced the chemotactic and paracrine characteristics of the cells in vitro but did not affect self-renewal or differentiation into alveolar and vascular endothelial cells. In vivo, CXCR4 improved MSC homing and colonization of damaged lung tissue, and furthermore, the transplanted CXCR4-MSCs suppressed the development of acute lung injury in part by modulating levels of inflammatory molecules and the neutrophil count. These results indicated that efficient mobilization of MSCs to sites of tissue injury may be due to CXCR4, and therefore, increased expression of CXCR4 may improve their therapeutic potential in the treatment of diseases where tissue damage develops.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	4
Volume Number	290
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2015-01-23
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Acute Lung Injury Therapy Mesenchymal Stromal Cells Cytology Receptors, CXCR4 Metabolism Animals Bone Marrow Bronchoalveolar Lavage Fluid Cell Differentiation Cell Membrane Cell Movement Cell Proliferation Chemotaxis Green Fluorescent Proteins Inflammation Lentivirus Lipopolysaccharides Chemistry Signal Transduction Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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CXCR4 Receptor Overexpression in Mesenchymal Stem Cells Facilitates Treatment of Acute Lung Injury in Rats

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