NDLI: Insect Gut Symbiont Susceptibility to Host Antimicrobial Peptides Caused by Alteration of the Bacterial Cell Envelope.

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Insect Gut Symbiont Susceptibility to Host Antimicrobial Peptides Caused by Alteration of the Bacterial Cell Envelope.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sturiale, Luisa Kim, Jiyeun Kate Cho, Jae Hyun Huh, Ye Rang Fukatsu, Takema Silipo, Alba Lee, Bok Luel Park, Ha Young Nakayama, Hiroshi Marchetti, Roberta Molinaro, Antonio Kim, Chan-hee Son, Dae Woo
Description	Author Affiliation: Kim JK ( From the Global Research Laboratory, College of Pharmacy, Pusan National University, Pusan 609-735, South Korea.); Son DW ( From the Global Research Laboratory, College of Pharmacy, Pusan National University, Pusan 609-735, South Korea.); Kim CH ( From the Global Research Laboratory, College of Pharmacy, Pusan National University, Pusan 609-735, South Korea.); Cho JH ( From the Global Research Laboratory, College of Pharmacy, Pusan National University, Pusan 609-735, South Korea.); Marchetti R ( the Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, Napoli 80126, Italy.); Silipo A ( the Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, Napoli 80126, Italy.); Sturiale L ( the CNR-Istituto per i Polimeri, Compositi e Biomateriali IPCB, Via P. Gaifami 18, Catania 95126, Italy.); Park HY ( From the Global Research Laboratory, College of Pharmacy, Pusan National University, Pusan 609-735, South Korea.); Huh YR ( From the Global Research Laboratory, College of Pharmacy, Pusan National University, Pusan 609-735, South Korea.); Nakayama H ( the Biomolecular Characterization Team, RIKEN Advanced Science Institute, Saitama 351-0198, Japan, and.); Fukatsu T ( the Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8566, Japan.); Molinaro A ( the Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, Napoli 80126, Italy.); Lee BL ( From the Global Research Laboratory, College of Pharmacy, Pusan National University, Pusan 609-735, South Korea, brlee@pusan.ac.kr.)
Abstract	The molecular characterization of symbionts is pivotal for understanding the cross-talk between symbionts and hosts. In addition to valuable knowledge obtained from symbiont genomic studies, the biochemical characterization of symbionts is important to fully understand symbiotic interactions. The bean bug (Riptortus pedestris) has been recognized as a useful experimental insect gut symbiosis model system because of its cultivatable Burkholderia symbionts. This system is greatly advantageous because it allows the acquisition of a large quantity of homogeneous symbionts from the host midgut. Using these naïve gut symbionts, it is possible to directly compare in vivo symbiotic cells with in vitro cultured cells using biochemical approaches. With the goal of understanding molecular changes that occur in Burkholderia cells as they adapt to the Riptortus gut environment, we first elucidated that symbiotic Burkholderia cells are highly susceptible to purified Riptortus antimicrobial peptides. In search of the mechanisms of the increased immunosusceptibility of symbionts, we found striking differences in cell envelope structures between cultured and symbiotic Burkholderia cells. The bacterial lipopolysaccharide O antigen was absent from symbiotic cells examined by gel electrophoretic and mass spectrometric analyses, and their membranes were more sensitive to detergent lysis. These changes in the cell envelope were responsible for the increased susceptibility of the Burkholderia symbionts to host innate immunity. Our results suggest that the symbiotic interactions between the Riptortus host and Burkholderia gut symbionts induce bacterial cell envelope changes to achieve successful gut symbiosis.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	34
Volume Number	290
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2015-08-21
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Burkholderia Chemistry Cell Wall Heteroptera Microbiology O Antigens Symbiosis Animals Antimicrobial Cationic Peptides Pharmacology Drug Effects Metabolism Physiology Cell Membrane Gastrointestinal Tract Immunology Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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