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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nie, Minghua Boddy, Michael N. |
| Description | Author Affiliation: Nie M ( From the Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037.); Boddy MN ( From the Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037 nboddy@scripps.edu.) |
| Abstract | Covalent modification of the proteome by SUMO is critical for genetic stability and cell growth. Equally crucial to these processes is the removal of SUMO from its targets by the Ulp1 (HuSENP1/2) family of SUMO proteases. Ulp1 activity is normally spatially restricted, because it is localized to the nuclear periphery via interactions with the nuclear pore. Delocalization of Ulp1 causes DNA damage and cell cycle defects, phenotypes thought to be caused by inappropriate desumoylation of nucleoplasmic targets that are normally spatially protected from Ulp1. Here, we define a novel consequence of Ulp1 deregulation, with a major impact on SUMO pathway function. In fission yeast lacking Nup132 (Sc/HuNUP133), Ulp1 is delocalized and can no longer antagonize sumoylation of the PIAS family SUMO E3 ligase, Pli1. Consequently, SUMO chain-modified Pli1 is targeted for proteasomal degradation by the concerted action of a SUMO-targeted ubiquitin ligase (STUbL) and Cdc48-Ufd1-Npl4. Pli1 degradation causes the profound SUMO pathway defects and associated centromere dysfunction in cells lacking Nup132. Thus, perhaps counterintuitively, Ulp1-mediated desumoylation can promote SUMO modification by stabilizing a SUMO E3 ligase. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 37 |
| Volume Number | 290 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2015-09-11 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cysteine Endopeptidases Metabolism SUMO-1 Protein Schizosaccharomyces Pombe Proteins Schizosaccharomyces Sumoylation Physiology Genetics Endopeptidases Protein Inhibitors Of Activated STAT Small Ubiquitin-Related Modifier Proteins Ubiquitin-Protein Ligases Research Support, N.I.H., Extramural Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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