NDLI: Synthesis and cytotoxicity of dinuclear complexes containing ruthenium( II) bipyridyl units linked by a bis(pyridylimine) ligand

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hannon, Michael J. Hicks, Matthew R. Mcdonnell, Ursula Hotze, Anna C. G. Kerchoffs, Jessica M. C. A. Rodger, Alison Castineiras, Rosa P. M.
Description	Author Affiliation: McDonnell U ( Department of Chemistry, University of Warwick, Coventry, UK. CV4 7AL.)
Abstract	Enantiopure dinuclear ruthenium polypyridyl complexes of the form $[Ru_{2}(LL)_{4}L^{1}](PF_{6})_{4}$ ( LL = 2,2′-bipyridine ( bpy ) or 1,10-phenanthroline ( phen ); $L^{1}$ = $C_{25}H_{20}N_{4}$ a bis(pyridylimine) ligand containing a diphenylmethane spacer) have been synthesized using the chiral building blocks cis-[Ru(bpy) $_{2}(py)$ $_{2}]$ $^{2+}$ and cis-[Ru(phen) $_{2}(py)$ $_{2}]$ $^{2+}$ . These dinuclear ruthenium complexes have been characterised using NMR , mass spectrometry , UV-visible absorbance, circular dichroism and linear dichroism . The compounds exhibit good photo and thermal stability. The extinction coefficient for the bpy complex at 478 nm is $ε_{478}$ = 15700 $mol^{−1}$ $cm^{−1}$ $dm^{3}$ and for the phen complex is $ε_{478}$ = 24900 $mol^{−1}$ $cm^{−1}$ $dm^{3}.$ Both complexes have their longest wavelength (metal to ligand charge transfer) transition predominantly x/y (short axis)-polarised while the transitions at shorter wavelength are a mixture of x/y and z-polarisations, similar to both the copper helicate and iron triple helicate studied previously. Cytotoxicity studies reveal that the compounds are dramatically less active against cancer cell lines than the recently reported supramolecular cylinders prepared from the same bis(pyridylimine) ligand.
ISSN	14779226
Issue Number	5
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2008-02-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Imines Chemistry Ruthenium Compounds Chemical Synthesis Toxicity Absorption Cell Line, Tumor Cell Proliferation Drug Effects Circular Dichroism Humans Ligands Spectrophotometry, Ultraviolet Temperature Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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