NDLI: myo-Inositol Oxygenase: a Radical New Pathway for $O_{2}$ and C-H Activation at a Nonheme Diiron Cluster

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myo-Inositol Oxygenase: a Radical New Pathway for $O_{2}$ and C-H Activation at a Nonheme Diiron Cluster

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Krebs, Carsten Diao, Yinghui Xing, Gang Bollinger, J. Martin Matthews, Megan L.
Description	Author Affiliation: Bollinger JM ( Department of Chemistry, The Pennsylvania State University, Pennsylvania, PA 16802, USA. jmb21@psu.edu)
Abstract	The enzyme myo-inositol oxygenase (MIOX) catalyzes conversion of myo-inositol (cyclohexan-1,2,3,5/4,6-hexa-ol or MI) to d-glucuronate (DG), initiating the only known pathway in humans for catabolism of the carbon skeleton of cell-signaling inositol (poly)phosphates and phosphoinositides. Recent kinetic, spectroscopic and crystallographic studies have shown that the enzyme activates its substrates, MI and O(2), at a carboxylate-bridged nonheme diiron(ii/iii) cluster, making it the first of many known nonheme diiron oxygenases to employ the mixed-valent form of its cofactor. Evidence suggests that: (1) the Fe(iii) site coordinates MI via its C1 and C6 hydroxyl groups; (2) the Fe(ii) site reversibly coordinates O(2) to produce a superoxo-diiron(iii/iii) intermediate; and (3) the pendant oxygen atom of the superoxide ligand abstracts hydrogen from C1 to initiate the unique C-C-bond-cleaving, four-electron oxidation reaction. This review recounts the studies leading to the recognition of the novel cofactor requirement and catalytic mechanism of MIOX and forecasts how remaining gaps in our understanding might be filled by additional experiments.
ISSN	14779226
e-ISSN	13645447
Journal	Dalton Trans.
Issue Number	6
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2009-02-14
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Inositol Oxygenase Chemistry Oxygen Catalysis Free Radicals Glucuronates Biosynthesis Hydrogen Inositol Metabolism Oxidation-Reduction Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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