NDLI: A set of highly water -soluble tetraethyleneglycol -substituted Zn(II) phthalocyanines : synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dumoulin, Fabienne Sooriyaarachchi, Melani Boyle, Ross W. Tuncel, Sinem Gailer, Jürgen Bouchu, Denis Ahsen, Vefa Durmus, Mahmut Atilla, Devrim Savoie, Huguette
Description	Author Affiliation: Tuncel S ( Gebze Institute of Technology, Department of Chemistry, P.O. Box 141, Gebze, 41400, Kocaeli, Turkey.)
Abstract	Three Zn(II) phthalocyanines substituted by hydroxyl -terminated tetraethylene glycol chains have been synthesized. In order to evaluate the potential of these highly water -soluble phthalocyanines as type II-photosensitisers for photodynamic therapy, their structure–activity relationship was assessed by determining relevant photophysical and photochemical properties, such as their aggregation behaviour in aqueous buffers , their fluorescence properties and their efficiency with regard to the generation of singlet oxygen . In addition, evidence for a negligible interaction with plasma proteins in undiluted human plasma was obtained using a recently developed bioanalytical method and compared with the fluorescence quenching approach. These results combined with in vitro data regarding the phototoxicity of these phthalocyanines against HT-29 cancer cells provide evidence for the relevance of the non-peripherally substituted derivative for further in vivo investigations.
ISSN	14779226
Issue Number	16
Volume Number	40
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2011-04-28
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Blood Proteins Metabolism Indoles Chemical Synthesis Organometallic Compounds Photochemical Processes Polyethylene Glycols Chemistry Water Absorption Animals Cattle Drug Design HT29 Cells Humans Pharmacology Photosensitizing Agents Protein Binding Serum Albumin, Bovine Singlet Oxygen Solubility Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in