NDLI: Methoxyquinoline - diethylenetriamine conjugate as a fluorescent zinc sensor

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yamashita, Azusa Kawata, Keiko Tamotsu, Satoshi Itami, Saori Konno, Hideo Yasuda, Keiko Mikata, Yuji
Description	Author Affiliation: Mikata Y ( KYOUSEI Science Center, Nara Women's University, Nara, 630-8506, Japan. mikata@cc.nara-wu.ac.jp)
Abstract	A 6-methoxyquinoline conjugated diethylenetriamine derivative, N, N′′-bis(6-methoxy-2-quinolylmethyl)diethylenetriamine (6-MeOBQDIEN) has been synthesized and its fluorescent response toward zinc ion was investigated. In the presence of zinc ion , 6-MeOBQDIEN exhibits fluorescence $(λ_{ex}$ = 329 nm, $λ_{em}$ = 418 nm, ϕ = 0.039). The fluorescent intensity of the zinc complex of the compound is two times higher than the parent BQDIEN (ϕ = 0.021) under the same conditions. The crystal structure of 6-MeOBQDIEN-Zn complex shows that all five nitrogen atoms participate to the metal coordination in a distorted square-pyramidal geometry (τ = 0.145) with the aliphatic nitrogen in an apical position. Fluorescent microscopic analysis using 6-MeOBQDIEN reveals the zinc ion concentration change in living cells.
ISSN	14779226
Issue Number	18
Volume Number	40
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2011-05-14
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Polyamines Chemistry Quinolines Zinc Animals Cell Line, Tumor Crystallography, X-Ray Hydrogen-Ion Concentration Molecular Conformation Chemical Synthesis Pharmacology Rats Spectrophotometry, Ultraviolet Journal Article
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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