NDLI: Thiolato gold(I) complexes containing water -soluble phosphane ligands : a characterization of their chemical and biological properties

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Laguna, Mariano Casini, Angela Vergara, Elena Cerrada, Elena Clavel, Catherine
Description	Author Affiliation: Vergara E ( Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH)-C.S.I.C, Universidad de Zaragoza, 50009, Zaragoza, Spain.)
Abstract	A series of thiolate gold(I) derivatives bearing water soluble phosphanes – namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) – is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, $[Au(SMe_{2}pyrim)(PTA)]$ and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis . Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands . ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.
ISSN	14779226
Issue Number	41
Volume Number	40
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2011-11-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Antineoplastic Agents Chemistry Coordination Complexes Gold Phosphines Chemical Synthesis Pharmacology Cell Line, Tumor Cell Proliferation Drug Effects Cisplatin Crystallography, X-Ray Drug Resistance, Neoplasm Female Humans Ligands Molecular Conformation Ovarian Neoplasms Water Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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