NDLI: Metal-based anti-diabetic drugs : advances and challenges

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Metal-based anti-diabetic drugs : advances and challenges

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Self assembled tetranuclear $Cu_{4}(II),$ $Ni_{4}(II)$ [2 × 2] square grids and a dicopper(II) complex of heterocycle based polytopic ligands - Magnetic studies

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Isomorphous tetrazolate $Mn^{II}$ and $Co^{II}$ compounds built on Δ-chain showing different magnetic behaviors

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Fraternal twin iridium hemicage chelates

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Metal-based anti-diabetic drugs : advances and challenges

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Levina, Aviva Lay, Peter A.
Description	Author Affiliation: Levina A ( School of Chemistry, The University of Sydney, NSW, Australia.)
Abstract	The current status and likely future directions of complexes of V(V/IV), Cr(III), Mo(VI), W(VI), Zn(II), Cu(II), and Mn(III) as potential oral drugs against type 2 diabetes are reviewed. We propose a unified model of extra- and intracellular mechanisms of anti-diabetic efficacies of V(V/IV), Mo(VI), W(VI), and Cr(III), centred on high-oxidation-state oxido /peroxido species that inhibit proteintyrosine phosphatases (PTPs) involved in insulin signalling. The postulated oxidative mechanism of anti-diabetic activity of Cr(III)via carcinogenic Cr(VI/V) (which adds to safety concerns) is consistent with recent clinical trials on Cr(III) picolinate, where activity was apparent only in patients with poorly controlled diabetes (high oxidative stress), and the correlation between the anti-diabetic activities and ease of oxidation of Cr(III) supplements and their metabolitesin vivo.Zn(II) and Cu(II) anti-diabetics act via different mechanisms and are unlikely to be used as specific anti-diabetics due to their diverse and unpredictable biological activities. Hence, future research directions are likely to centre on enhancing the bioavailability and selectivity of V(V/IV), Mo(VI), or W(VI) drugs . The strategy of potentiating circulating insulin with metal ions has distinct therapeutic advantages over interventions that stimulate the release of more insulin, or use insulin mimetics, because of many adverse side-effects of increased levels of insulin, including increased risks of cancer and cardiovascular diseases.
ISSN	14779226
Issue Number	44
Volume Number	40
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2011-11-28
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Coordination Complexes Therapeutic Use Diabetes Mellitus, Type 2 Drug Therapy Hypoglycemic Agents Chemistry Metabolism Humans Metals Protein Tyrosine Phosphatases Antagonists & Inhibitors Journal Article Research Support, Non-U.S. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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