NDLI: 17 $e^{−}rhenium$ dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Blacque, Olivier Bogdanova, Anna Yu Schaub, Marcus C. Zobi, Fabio Jacobs, Robert A.
Description	Author Affiliation: Zobi F ( Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland. fzobi@aci.uzh.ch)
Abstract	Cyanocobalamin $(B_{12})$ offers a biocompatible scaffold for CO-releasing 17-electron dicarbonyl complexes based on the $cis-trans-[Re^{II}(CO)_{2}Br_{2}]^{0}$ core. A Co–C≡N–Re conjugate is produced in a short time and high yield from the reaction of $[Et_{4}N]_{2}[Re^{II}Br_{4}(CO)_{2}]$ (ReCORM-1) with $B_{12}.$ The $B_{12}-Re^{II}(CO)_{2}$ derivatives show a number of features which make them pharmaceutically acceptable CO-releasing molecules (CORMs). These cobalamin conjugates are characterized by an improved stability in aqueous aerobic media over the metal complex alone, and afford effective therapeutic protection against ischemia-reperfusion injury in cultured cardiomyocytes. The non-toxicity (at μM concentrations) of the resulting metal fragment after CO release is attributed to the oxidation of the metal and formation in solution of the $ReO_{4}^{−}$ anion, which is among the least toxic of all of the rare inorganic compounds. Theoretical and experimental studies aimed at elucidating the aqueous chemistry of ReCORM-1 are also described.
ISSN	14779226
Issue Number	2
Volume Number	41
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2012-01-14
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Carbon Monoxide Chemistry Organometallic Compounds Pharmacology Rhenium Vitamin B 12 Animals Animals, Newborn Cell Survival Drug Effects Cells, Cultured Cytoprotection Drug Design Drug Stability Models, Molecular Molecular Structure Myocytes, Cardiac Pathology Chemical Synthesis Toxicity Oxidative Stress Rats Reperfusion Injury Prevention & Control Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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