NDLI: Coordination bonding based pH-responsive albumin nanoparticles for anticancer drug delivery

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Che, Shunai Li, Chenguang Xing, Lei
Description	Author Affiliation: Li C ( School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, PR China.)
Abstract	Zn-loaded bovine serum albumin nanoparticles (Zn–BSA nanoparticles ) were prepared and used as carriers for pH-responsive anticancer drug delivery. Zinc was introduced into this system to increase the stability of the BSA nanoparticles and to load the anticancer drug based on the coordination bonding formation of Zn–BSA and Zn– drug molecules, respectively. The cleavage of either the “Zn–BSA” or the “Zn– drug ” coordination bonding, in response to pH, would result in the release of the drug under designated pH conditions. The nanoparticles were spherical with diameters of 50–60 nm and narrow size distribution. Mitoxantrone (MX) was chosen as the model drug to study the release behavior and the inhibitory efficacy against tumor cells. In vitro release behavior of MX loaded Zn–BSA nanoparticles (MX–Zn–BSA nanoparticles ) showed a fine pH-responsiveness. The release amount at pH 5.0 was close to 80%, while the cumulative release amount at pH 7.4 was less than 6% within 24 h. The blank Zn–BSA nanoparticles were of low cytotoxicity, while a high cytotoxic activity of MX–Zn–BSA nanoparticles against MCF-7 cells was demonstrated by in vitro cell assays.
ISSN	14779226
Issue Number	13
Volume Number	41
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2012-04-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Antineoplastic Agents Chemistry Drug Carriers Nanoparticles Serum Albumin, Bovine Animals Pharmacology Cattle Cell Line, Tumor Cell Survival Drug Effects Chemical Synthesis Humans Hydrogen-Ion Concentration Mitoxantrone Models, Molecular Molecular Conformation Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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