NDLI: Remarkable in vitro bactericidal activity of bismuth(III) sulfonates against Helicobacter pylori

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Deacon, Glen B. Ferrero, Richard L. Andrews, Philip C. Vom, Amelia Maclellan, Jonathan G. Busse, Madleen Junk, Peter C.
Description	Author Affiliation: Andrews PC ( School of Chemistry, Monash University, Melbourne, VIC 3800, Australia. phil.andrews@monash.edu)
Abstract	Four new tris-substituted bismuth(III) sulfonates of general formula $[Bi(O_{3}SR)_{3}]$ (R = phenyl 1, p-tolyl 2, 2,4,6-mesityl 3 and S-(+)-10-camphoryl 4) have been synthesised and characterised. Their synthesis by solvent -free (SF) and solvent -mediated (SM) methods has been explored and their activity against Helicobacter pylori has been investigated. The compounds 1–4 display a remarkable in vitro activity against three laboratory strains of H. pylori (B128, 26695 and 251) with minimum inhibitory concentration (MIC) values as low as 0.049 μg $mL^{−1}$ for the strains B128 and 26695, and 0.781 μg $mL^{−1}$ for the clinical isolate 251. This places most MIC values in the nano-molar region and demonstrates the strong influence of the sulfonate group on the bactericidal properties. The novel solid state structure $[Bi_{8}(O_{3}SMes)_{20}(SO_{4})_{2}(H_{2}O)_{6}]·(C_{7}H_{8})_{7}5·(C_{7}77H_{8}88)_{7}77,$ derived from the SM reaction under reflux conditions, is presented and the incorporation of the two inorganic sulfate anions in the centre of the wheel-like bismuth sulfonate cluster explained.
ISSN	14779226
Issue Number	38
Volume Number	41
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2012-10-14
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Anti-Bacterial Agents Chemistry Bismuth Coordination Complexes Helicobacter Pylori Drug Effects Sulfonic Acids Chemical Synthesis Toxicity Crystallography, X-Ray Helicobacter Infections Microbiology Isolation & Purification Microbial Sensitivity Tests Molecular Conformation Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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