NDLI: New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tolazzi, Marilena Villette, Sandrine Melchior, Andrea Di Bernardo, Plinio Marques, Sérgio M. Chaves, Sílvia Tóth, Éva Santos, M. Amélia Mendonça, Ana C. Petoud, Stéphane Geraldes, Carlos F. G. C. Martins, André F. Bonnet, Célia S. Zanonato, Pier Luigi
Description	Author Affiliation: Mendonça AC ( Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.)
Abstract	There is a growing interest in the development of new medical diagnostic tools with higher sensibility and less damage for the patient body, namely on imaging reporters for the management of diseases and optimization of treatment strategies. This article examines the properties of a new class of lanthanide complexes with a tripodal tris-3-hydroxy-4-pyridinone (tris-3,4-HOPO) ligand – $NTP(PrHP)_{3}.$ Among the studies herein performed, major relevance is given to the thermodynamic stability of the complexes with a series of $Ln^{3+}$ ions (Ln = La, Pr, Gd, Er, Lu) and to the magnetic relaxation properties of the $Gd^{3+}$ complex. This hexadentate ligand enables the formation of (1:1) $Ln^{3+}$ complexes with high thermodynamic stability following the usual trend, while the Gd-chelates show improved relaxivity (higher hydration number), as compared with the commercially available Gd-based contrast agents (CAs); transmetallation of the $Gd^{3+}–L$ complex with $Zn^{2+}$ proved to be thermodynamically and kinetically disfavored. Therefore, $NTP(PrHP)_{3}$ emerges as part of a recently proposed new generation of CAs with prospective imaging sensibility gains.
ISSN	14779226
Issue Number	17
Volume Number	42
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-05-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Contrast Media Chemical Synthesis Coordination Complexes Chemistry Lanthanoid Series Elements Magnetics Pyridones Diagnostic Imaging Gadolinium Humans Hydrogen-Ion Concentration Kinetics Ligands Thermodynamics Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in