NDLI: Preliminary anti-cancer photodynamic therapeutic in vitro studies with mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes.

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Preliminary anti-cancer photodynamic therapeutic in vitro studies with mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Smith, Paul F. Moffett, Erick T. Williams, Jennie L. Menocal, Laura Seymour, Luke A. Ji, Ping Cropek, Donald M. Dismukes, G. Charles Gordon, Michelle Jarrett, William L. Weber, Ralph T. Bai, Fengwei Stubbs, Javelyn Taylor, Patrick Hong, Yiling Acharya, Dhiraj Magnusen, Anthony R. Holder, Alvin A. Ramsdale, Stuart E. Meyer, Kyle
Description	Author Affiliation: Holder AA ( Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive, #5043, Hattiesburg, Mississippi 39406-0001, USA. alvin.holder@usm.edu)
Abstract	We report the synthesis and characterisation of mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes, which were used as potential photodynamic therapeutic agents for melanoma cell growth inhibition. The novel complexes, [Ru(pbt)2(phen2DTT)](PF6)2·1.5H2O 1 (where phen2DTT = 1,4-bis(1,10-phenanthrolin-5-ylsulfanyl)butane-2,3-diol and pbt = 2-(2'-pyridyl)benzothiazole) and [Ru(pbt)2(tpphz)](PF6)2·3H2O 2 (where tpphz = tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) were synthesised and characterised. Compound 1 was reacted with [VO(sal-L-tryp)(H2O)] (where sal-L-tryp = N-salicylidene-L-tryptophanate) to produce [Ru(pbt)2(phen2DTT)VO(sal-L-tryp)](PF6)2·5H2O 4; while [VO(sal-L-tryp)(H2O)] was reacted with compound 2 to produce [Ru(pbt)2(tpphz)VO(sal-L-tryp)](PF6)2·6H2O 3. All complexes were characterised by elemental analysis, HRMS, ESI MS, UV-visible absorption, ESR spectroscopy, and cyclic voltammetry, where appropriate. In vitro cell toxicity studies (with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay) via dark and light reaction conditions were carried out with sodium diaqua-4,4',4'',4''' tetrasulfophthalocyaninecobaltate(II) (Na4[Co(tspc)(H2O)2]), [VO(sal-L-tryp)(phen)]·H2O, and the chloride salts of complexes 3 and 4. Such studies involved A431, human epidermoid carcinoma cells; human amelanotic malignant melanoma cells; and HFF, non-cancerous human skin fibroblast cells. Both chloride salts of complexes 3 and 4 were found to be more toxic to melanoma cells than to non-cancerous fibroblast cells, and preferentially led to apoptosis of the melanoma cells over non-cancerous skin cells. The anti-cancer property of the chloride salts of complexes 3 and 4 was further enhanced when treated cells were exposed to light, while no such effect was observed on non-cancerous skin fibroblast cells. ESR and (51)V NMR spectroscopic studies were also used to assess the stability of the chloride salts of complexes 3 and 4 in aqueous media at pH 7.19. This research illustrates the potential for using mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes to fight skin cancer.
ISSN	14779226
e-ISSN	13645447
Journal	Dalton Trans.
Issue Number	33
Volume Number	42
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-09-07
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Antineoplastic Agents Pharmacology Organometallic Compounds Photochemotherapy Photosensitizing Agents Ruthenium Chemistry Vanadium Chemical Synthesis Cell Line, Tumor Cell Proliferation Drug Effects Cell Survival Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Electrochemical Techniques Molecular Structure Structure-Activity Relationship Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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