NDLI: Synthesis of mesoporous hollow silica nanospheres using polymeric micelles as template and their application as a drug -delivery carrier

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nakashima, Kenichi Bhaumik, Asim Sasidharan, Manickam Zenibana, Haruna Nandi, Mahasweta
Description	Author Affiliation: Sasidharan M ( Department of Chemistry, Faculty of Science and Engineering, Saga University, 1 Honjo-machi, Saga 840-8502, Japan.)
Abstract	Mesoporous hollow silica nanospheres with uniform particle sizes of 31–33 nm have been successfully synthesized by cocondensation of tetramethoxysilane (TMOS) and alkyltrimethoxysilanes $[RSi(OR)_{3}],$ where the latter also acts as a porogen. ABC triblock copolymer micelles of poly(styrene-b-2-vinyl pyridine-b-ethylene oxide) ( PS –PVP–PEO) with a core–shell–corona architecture have been employed as a soft template at pH 4. The cationic shell block with 2-vinyl pyridine groups facilitates the condensation of silica precursors under the sol–gel reaction conditions. Phenyltrimethoxysilane , octyltriethoxysilane , and octadecyltriethoxysilanes were used as porogens for generating mesopores in the shell matrix of hollow silica and the octadecyl precursor produced the largest mesopore among the different porogens, of dimension ca. 4.1 nm. The mesoporous hollow particles were thoroughly characterized by small-angle X-ray diffraction ( SXRD ), thermal ( TG / DTA ) and nitrogen sorption analyses, infra-red ( FTIR ) and nuclear magnetic resonance $(^{13}C-CP$ MAS NMR and $^{29}Si$ MAS NMR ) spectroscopies, and transmission electron microscopy ( TEM ). The mesoporous hollow silica nanospheres have been investigated for drug -delivery application by an in vitro method using ibuprofen as a model drug . The hollow silica nanospheres exhibited higher storage capacity than the well-known mesoporous silica MCM-41. Propylamine functionalized hollow particles show a more sustained release pattern than their unfunctionalized counterparts, suggesting a huge potential of hollow silica nanospheres in the controlled delivery of small drug molecules.
ISSN	14779226
Issue Number	37
Volume Number	42
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-10-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Drug Carriers Chemistry Drug Delivery Systems Nanoparticles Polymers Silicon Dioxide Micelles Particle Size Porosity Surface Properties Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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