NDLI: CPMV-induced synthesis of hollow mesoporous $SiO_{2}$ nanocapsules with excellent performance in drug delivery

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kumar, Koushi Kumar Doddi, Shanmukha Paik, Pradip Arunasree, Marasanapalli Kalle
Description	Author Affiliation: Kumar K ( School of Engineering Sciences and Technology, University of Hyderabad, India.)
Abstract	Hollow $mesoporous-SiO_{2}$ nanocapsules have been synthesized at room temperature using unmodified cowpea Mosaic Virus (CPMV) as a template, and without using any catalyst or surfactant during the synthesis. The average size of the capsules synthesized was ∼200–250 nm with a 60–100 nm hollow core. The resulting nanocapsules were characterized using high resolution transmission electron microscopy (HRTEM). The biocompatibility of the hollow mesoporous $SiO_{2}$ nanocapsules was investigated with an MTT assay using the RAW 264.7 cells, HepG2 cells (human liver carcinoma cells), and Hek293 cells (human embryonic kidney cells). The nanocapsules were loaded with fluorescent molecules (rhodamine 6G), doxorubicin (DOX) – an anticancer drug, and chloroquine diphosphate (CQDP) – an antimalarial drug, and their release was studied using a UV-Vis spectrometer. The development of surfactant free, bio-safe, hollow and mesoporous $SiO_{2}$ nanocapsules with CPMV provides a route for the synthesis of porous nanocapsules for drug loading and the sustained delivery of drugs. The synthesis method for hollow mesoporous $SiO_{2}$ nanocapsules using CPMV is novel, straightforward, and further demonstrates that, in general, nanoformulated capsules can be used for various drug-delivery-based therapeutic applications. To check the in vitro efficacy in medical biotechnology, Hek293 and HepG2 cell lines were used to study the cell viability of DOX-loaded hollow silica nanocapsules. The results show that the bio $SiO_{2}$ nanocapsules synthesized with CPMV present an effective cargo and are suitable for nanoformulating with DOX, with the resultant nanoformulation showing good promise for killing cancer specific cells.
ISSN	14779226
Issue Number	9
Volume Number	44
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-03-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Comovirus Nanocapsules Chemistry Silicon Dioxide Animals Antimalarials Administration & Dosage Antineoplastic Agents Cell Line Cell Survival Drug Effects Chloroquine Analogs & Derivatives Doxorubicin Drug Delivery Systems Fluorescent Dyes HEK293 Cells Hep G2 Cells Humans Mice Porosity Rhodamines Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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