NDLI: Metal ion-assisted ring-opening of a quinazoline-based chemosensor: detection of copper(II) in aqueous media

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zheng, Xiang-jun Fang, De-cai Jin, Lin-pei Cao, Wei
Description	Author Affiliation: Cao W ( Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing, 100875, People's Republic of China. xjzheng@bnu.edu.cn dcfang@bnu.edu.cn.)
Abstract	A quinazoline-based fluorescence chemosensor, 6-phenol-2-yl-(5,6-dihydrobenzimidazo[1,2-c])quinazoline (HL), for highly selective recognition of Cu(II) in aqueous media was synthesized. The detection limit was of the order of $10^{−6}$ M. The crystal structures of the Cu(II) and Cd(II) complexes showed that HL changed to a Schiff base when it reacts with metal salts and that the metal ions coordinate with two nitrogen atoms and one hydroxyl oxygen atom from the Schiff base. The theoretical calculations at B3LYP-SCRF/6-31G(d) confirmed that it is the Cu(II) ion that assisted the ring-opening of the quinazoline derivative, forming a Cu(II) Schiff base complex during the detection. LMCT leads to the disappearance of fluorescence. A cell imaging study indicated that HL could be used to detect the intracellular $Cu^{2+}$ ion.
ISSN	14779226
Issue Number	11
Volume Number	44
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-03-21
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Benzimidazoles Chemistry Cadmium Chemistry Techniques, Analytical Instrumentation Copper Analysis Quinazolines Water HeLa Cells Humans Intracellular Space Models, Molecular Molecular Conformation Molecular Imaging Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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