NDLI: Composite silica coated gold nanosphere and quantum dots nanoparticles for X-ray CT and fluorescence bimodal imaging

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Xiao-quan Song, Ji-tao Zhao, Yuan-di Yao, Ming-hao Yan, Dong-mei Zhang, Xiao-shuai Qin, Meng-yao
Description	Author Affiliation: Song JT ( Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China. zydi@mail.hust.edu.cn.)
Abstract	In this study, silica coated Au nanospheres $(Au@SiO_{2})$ were prepared by a reverse microemulsion method; subsequently, a layer of fluorescent quantum dots (QDs) were adsorbed onto it and then it was coated with silica again. After modifying with PVP, the composite silica coated gold nanosphere and quantum dots nanoparticle $(Au@SiO_{2}-QDs/SiO_{2}-PVP)$ was obtained. This composite structure contained Au and QDs, and it could be used for contrast-enhanced X-ray CT imaging and fluorescence imaging. Characterization showed that the composite nanoparticle had good dispersity, a high fluorescence intensity and a good effect of X-ray absorption, and it was suitable for using as a bimodal imaging probe.
ISSN	14779226
Issue Number	25
Volume Number	44
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-07-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Fluorescent Dyes Chemistry Gold Nanoparticles Quantum Dots Silicon Dioxide Animals Cell Line Cell Survival Drug Effects Contrast Media Toxicity Diatrizoate Meglumine Emulsions Mice Ultrastructure Optical Imaging Povidone Spectroscopy, Fourier Transform Infrared Tomography, X-Ray Computed Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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