NDLI: The cytotoxicity of gold nanoparticles is dispersity-dependent

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, Hualu Gao, Jinhao Huang, Dengtong Liu, Hanyu
Description	Author Affiliation: Huang D ( State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. jhgao@xmu.edu.cn.)
Abstract	Nanoparticles are generally dispersed in electrolyte solutions for cell research. They may be aggregated and thus strongly influence the subsequent bio-effects. However, this has been often neglected in nanotoxicity research. In this paper, we selected gold nanoparticles as an example and investigated the role of dispersity in cytotoxicity. Our data indicated that the cytotoxicity of aggregated gold nanoparticles is significantly higher than well-dispersed ones. The dispersity-dependent cytotoxicity may be related to the increase of cellular endocytosis and reactive oxygen species. These results highlighted the importance of the dispersity of nanoparticles in nanotoxicity and nanobiotechnology fields.
ISSN	14779226
Issue Number	41
Volume Number	44
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-11-07
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Cell Survival Drug Effects Gold Toxicity Metal Nanoparticles Chemistry HeLa Cells Humans Hydrodynamics Ultrastructure Particle Size Solubility Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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