NDLI: Magnetic nanoscale metal organic frameworks for potential targeted anticancer drug delivery, imaging and as an MRI contrast agent

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ray Chowdhuri, Angshuman Sahu, Sumanta Kumar Bhattacharya, Dipsikha
Description	Author Affiliation: Ray Chowdhuri A ( Department of Applied Chemistry, Indian School of Mines, Dhanbad 826 004, Jharkhand, India. sahu.s.ac@ismdhanbad.ac.in sumantchem@gmail.com.)
Abstract	The development of a novel multifunctional porous nanoplatform for targeted anticancer drug delivery with cell imaging and magnetic resonance imaging has been realised in the current work. Here we have developed a magnetic nanoscale metal organic frameworks (NMOF) for potential targeted drug delivery. These magnetic NMOFs were fabricated by incorporation of $Fe_{3}O_{4}$ nanoparticles into porous isoreticular metal organic frameworks (IRMOF-3). To achieve targeted drug delivery towards cancer cells specifically, folic acid was conjugated to the NMOF surface. Then, the fluorescent molecule rhodamine B isothiocyanate (RITC) was conjugated to the NMOFs for biological imaging applications. The synthesized magnetic NMOFs were fully characterised by FTIR, powder XRD, XPS, SQUID, TGA, TEM, FESEM, and DLS. The synthesized magnetic NMOFs were observed to be smaller than 100 nm and were found to be nontoxic towards human cervix adenocarcinoma (HeLa) and murine fibroblast (NIH3T3) cells according to cell viability assays. The cancer chemotherapy drug paclitaxel was conjugated to the magnetic NMOFs through hydrophobic interactions with a relatively high loading capacity. Moreover, these folic acid-conjugated magnetic NMOFs showed stronger T2-weighted MRI contrast towards the cancer cells, justifying their possible significance in imaging.
ISSN	14779226
Issue Number	7
Volume Number	45
e-ISSN	13645447
Journal	Dalton Trans.
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-02-21
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Antineoplastic Agents Administration & Dosage Contrast Media Chemistry Drug Carriers Magnetic Resonance Imaging Magnetite Nanoparticles Organometallic Compounds Paclitaxel Animals Pharmacology Cell Survival Drug Effects Chemical Synthesis Folic Acid HeLa Cells Humans Mice NIH 3T3 Cells Surface Properties Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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