NDLI: Another step toward DNA selective targeting: $Ni^{II}$ and $Cu^{II}$ complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Terenzi, Alessio Roller, Alexander Berger, Walter Barone, Giampaolo Van Schoonhoven, Sushilla Kowol, Christian R. Lötsch, Daniela Keppler, Bernhard K.
Description	Author Affiliation: Terenzi A ( Institute of Inorganic Chemistry, University of Vienna, Waehringerstr. 42, A-1090 Vienna, Austria. alessio.terenzi@univie.ac.at and Research Platform 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, Vienna, Austria.); Lötsch D ( Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.); van Schoonhoven S ( Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.); Roller A ( Institute of Inorganic Chemistry, University of Vienna, Waehringerstr. 42, A-1090 Vienna, Austria. alessio.terenzi@univie.ac.at.); Kowol CR ( Institute of Inorganic Chemistry, University of Vienna, Waehringerstr. 42, A-1090 Vienna, Austria. alessio.terenzi@univie.ac.at and Research Platform 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, Vienna, Austria.); Berger W ( Research Platform 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, Vienna, Austria and Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.); Keppler BK ( Institute of Inorganic Chemistry, University of Vienna, Waehringerstr. 42, A-1090 Vienna, Austria. alessio.terenzi@univie.ac.at and Research Platform 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, Vienna, Austria.); Barone G ( Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Viale delle Scienze, Edificio 17, 90128 Palermo, Italy. giampaolo.barone@unipa.it.)
Abstract	DNA G-rich sequences are able to form four-stranded structures organized in stacked guanine tetrads. These structures, called G-quadruplexes, were found to have an important role in the regulation of oncogenes expression and became, for such a reason, appealing targets for anticancer drugs. Aiming at finding selective G-quadruplex binders, we have designed, synthesized and characterized a new water soluble Salen-like Schiff base ligand and its $Ni^{II}$ and $Cu^{II}$ metal complexes. UV-Vis, circular dichroism and FRET measurements indicated that the nickel complex can stabilize oncogene promoter G-quadruplexes with high selectivity, presenting no interactions with duplex DNA at all. The same compound exhibited dose-dependent cytotoxic activity in MCF-7 breast cancer cells when combined with lipofectamine as lipophilic carrier.
ISSN	14779226
Issue Number	18
Journal	Dalton Trans.
Volume Number	45
e-ISSN	13645447
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-05-04
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Chemistry
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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