NDLI: A new quinoline-based fluorescent probe for $Cd^{2+}$ and $Hg^{2+}$ with an opposite response in a 100% aqueous environment and live cell imaging

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Wei-kang Tan, Xing-xing Zhang, Mao-lin Zhang, Mei Luo, Xiao-fei Lu, Hong-lin Zang, Shuang-quan
Description	Author Affiliation: Lu HL ( College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China. zangsqzg@zzu.edu.cn zhangm@zzu.edu.cn.); Wang WK ( Medical College, Zhengzhou University, Zhengzhou 450001, China.); Tan XX ( College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China. zangsqzg@zzu.edu.cn zhangm@zzu.edu.cn.); Luo XF ( College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China. zangsqzg@zzu.edu.cn zhangm@zzu.edu.cn.); Zhang ML ( College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China. zangsqzg@zzu.edu.cn zhangm@zzu.edu.cn.); Zhang M ( College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China. zangsqzg@zzu.edu.cn zhangm@zzu.edu.cn.); Zang SQ ( College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China. zangsqzg@zzu.edu.cn zhangm@zzu.edu.cn.)
Abstract	A new quinoline-based fluorescent probe L was synthesized and characterized. Probe L showed opposite fluorescence responses toward $Cd^{2+}$ (turn-on) and $Hg^{2+}$ (turn-off) in a 100% aqueous environment. X-ray crystallography analysis and TD-DFT calculations showed the different mechanisms of CHEF-based for $L–Cd^{2+}$ and PET-based for $L–Hg^{2+}$ caused by different binding modes and different electronic transfer patterns. The detection limits for the analysis of $Cd^{2+}$ and $Hg^{2+}$ ions were found to be 3.9 × $10^{−8}$ M and 9.8 × $10^{−7}$ M, respectively. Its in vivo sensitivities to $Cd^{2+}$ and $Hg^{2+}$ were demonstrated in the EC9706 cell line with the use of a laser scanning fluorescence microscope.
ISSN	14779226
Issue Number	19
Journal	Dalton Trans.
Volume Number	45
e-ISSN	13645447
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-05-10
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Chemistry
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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