NDLI: Mechanochemical synthesis of mesoporous tin oxide: a new generation nanosorbent for $^{68}Ge/^{68}Ga$ generator technology

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mazumder, Subhasish Chakraborty, Sudipta Tyagi, Avesh Kumar Shukla, Rakesh Bahadur, Jitendra Ram, Ramu Dev Sarma, Haladhar Chakravarty, Rubel Dash, Ashutosh
Description	Author Affiliation: Chakravarty R ( Isotope Production and Applications Division, Bhabha Atomic Research Centre, Trombay, Mumbai - 400 085, India. adash@barc.gov.in rubelc@barc.gov.in.)
Abstract	The present article reports the synthesis and characterization of mesoporous tin oxide (MTO) nanoparticles by a solid-state mechanochemical route. The synthesized material was used as an advanced sorbent material for $^{68}Ge/^{68}Ga$ radionuclide generator technology. Gallium-68 $(t_{½}$ = 68 min) obtained from the $^{68}Ge/^{68}Ga$ generator is an important diagnostic radioisotope which holds tremendous potential in the non-invasive monitoring of various diseases, including cancer, using positron emission tomography (PET). The crystallite size of the MTO nanoparticles was in the range of 6–12 nm with a large surface area of 265 ± 16 $m^{2}$ $g^{−1},$ while the mean pore radius was found to be 2.1 ± 0.6 nm. Determination of the zeta-potential of the MTO nanoparticles dispersed in solutions at different pH values aided in understanding the sorption and separation mechanisms, which were based on the surface charge developed on the nanosorbent. The sorption capacity observed under column-flow conditions was 85 ± 5 mg Ge per g of nanosorbent. A clinical-scale $^{68}Ge/^{68}Ga$ generator (740 MBq) was developed using this nanosorbent. Gallium-68 could be regularly eluted from this generator over a prolonged period of 1 year with >70% elution yield and met all the requirements for clinical use. The suitability of $^{68}Ga$ obtained from it was evaluated in preclinical settings by the preparation of a $^{68}Ga-labeled$ peptide containing the arginine-glycine-aspartic acid (RGD) motif. To the best of our knowledge, this is the first report on the synthesis of MTO nanoparticles by a mechanochemical route which could be effectively utilized for the routine preparation of clinical-scale $^{68}Ge/^{68}Ga$ generators. The promising results obtained in this study would facilitate greater implementation of mechanochemistry for the synthesis of nanosorbents for radionuclide generator technology since this method is simple, economical and convenient.
ISSN	14779226
Issue Number	34
Journal	Dalton Trans.
Volume Number	45
e-ISSN	13645447
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-09-14
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Chemistry
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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