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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Samsonov, Sergey Vagt, Toni Nyakatura, Elisabeth Koksch, Beate Fleige, Emanuel Numata, Jorge Cölfen, Helmut Pisabarro, M. Teresa Salwiczek, Mario |
| Description | Author Affiliation: Salwiczek M ( Department of Biology, Chemistry, and Pharmacy, Freie Universiät Berlin, Institute of Chemistry and Biochemistry-Organic Chemistry, Takustrasse 3, 14195 Berlin, Germany.) |
| Abstract | Systematic model investigations of the molecular interactions of fluorinated amino acids within native protein environments substantially improve our understanding of the unique properties of these building blocks. A rationally designed heterodimeric coiled coil peptide (VPE/VPK) and nine variants containing amino acids with variable fluorine content in either position a16 or d19 within the hydrophobic core were synthesized and used to evaluate the impact of fluorinated amino acid substitutions within different hydrophobic protein microenvironments. The structural and thermodynamic stability of the dimers were examined by applying both experimental (CD spectroscopy, FRET, and analytical ultracentrifugation) and theoretical (MD simulations and MM-PBSA free energy calculations) methods. The coiled coil environment imposes position-dependent conformations onto the fluorinated side chains and thus affects their packing and relative orientation towards their native interaction partners. We find evidence that such packing effects exert a significant influence on the contribution of fluorine-induced polarity to coiled coil folding. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 31 |
| Volume Number | 15 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2009-08-03 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Amino Acids Chemistry Hydrocarbons, Fluorinated Proteins Hydrophobic And Hydrophilic Interactions Models, Chemical Protein Structure, Secondary Thermodynamics Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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