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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hoffmann-röder, Anja Wagner, Sarah Mersch, Christian |
| Description | Author Affiliation: Wagner S ( Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.) |
| Abstract | The aberrant glycosylation profiles of mucin glycoproteins on epithelial tumour cells represent attractive target structures for the development of immunotherapy against cancer. Mucin-type glycopeptides have been successfully investigated as molecularly defined vaccine prototypes for triggering humoral immunity but are susceptible to rapid in vivo degradation. As a potential means to enhance the bioavailabilities of the antigenic structures, hydrolysis-resistant carbohydrate analogues with fluorine substituents at positions C6, C2′ and C6′ were synthesised and incorporated into the tandem repeat sequence of the mucin MUC1. The resulting pseudo-glycopeptides can be used to elucidate the effects of chemically modified antibody determinants on metabolic and immunological properties. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 24 |
| Volume Number | 16 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2010-06-25 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Amino Acids Chemistry Antigens, Tumor-Associated, Carbohydrate Immunology Glycopeptides Mucin-1 Amino Acid Sequence Glycosylation Halogenation Magnetic Resonance Spectroscopy Neoplasms Structure-Activity Relationship Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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