NDLI: Magnetic Electrochemiluminescent $Fe_{3}O_{4}/CdSe–CdS$ Nanoparticle/Polyelectrolyte Nanocomposite for Highly Efficient Immunosensing of a Cancer Biomarker

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Magnetic Electrochemiluminescent $Fe_{3}O_{4}/CdSe–CdS$ Nanoparticle/Polyelectrolyte Nanocomposite for Highly Efficient Immunosensing of a Cancer Biomarker

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Lei Jie, Guifen Zhang, Shusheng
Description	Author Affiliation: Jie G ( State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, PR China.)
Abstract	Magnetic electrochemiluminescent $Fe_{3}O_{4}/CdSe–CdS$ nanoparticle/polyelectrolyte nanostructures have been synthesized and used to fabricate an electrochemiluminescence (ECL) immunosensor for the detection of carcinoembryonic antigen (CEA). CEA is a protein used as a biomarker for several cancers; particularly, to monitor response to treatment in colon and rectal cancer patients. The nanocomposites can be easily separated and firmly attached to an electrode owing to their excellent magnetic properties. This represents a promising advantage for bioassay applications. More importantly, the nanostructures exhibit intense and stable ECL emissions in neutral solution, which makes them ideal for ECL immunosensing. The 3-aminopropyltriethoxysilane (APS) polyelectrolyte shell on the nanostructure surface not only enhances the intensity and stability of the ECL signal, but also acts as a crosslinker for immunosensor fabrication. A CEA antibody immobilized onto a nanocomposite/APS/electrode with gold nanoparticles comprises the ECL immunosensor. The principle of ECL detection for CEA is based on a change in steric hindrance after immunoreaction, which leads to a decrease in ECL intensity. A wide detection range $(0.064 pg ml^{−1}–10 ng ml^{−1})$ and low detection limit $(0.032 pg ml^{−1})$ are achieved. The immunosensor is highly sensitive and selective, and exhibits excellent stability and good reproducibility. It thus has great potential for clinical protein detection. In particular, this approach uses a novel class of bifunctional nanocomposites that display both intense ECL and excellent magnetism, which renders them suitable for a large range of bioassay applications.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	2
Volume Number	17
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2011-01-10
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Carcinoembryonic Antigen Ferrosoferric Oxide Chemistry Nanocomposites Tumor Markers, Biological Biosensing Techniques Colonic Neoplasms Diagnosis Luminescent Measurements Rectal Neoplasms Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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Magnetic Electrochemiluminescent $Fe_{3}O_{4}/CdSe–CdS$ Nanoparticle/Polyelectrolyte Nanocomposite for Highly Efficient Immunosensing of a Cancer Biomarker

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