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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sakaguchi, Ikumi Fujimoto, Kazuhisa Kajino, Masaoki Inouye, Masahiko |
| Description | Author Affiliation: Fujimoto K ( Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kyushu Sangyo University, Matsukadai 2-3-1, Fukuoka 813-8503, Japan. kazuf@ip.kyusan-u.ac.jp) |
| Abstract | Diarylethene-bridged peptides were developed to photoregulate biomolecular interactions. The peptides are made up of diarylethene-bridged and DNA-binding regions at their N- and C termini, respectively. The two regions could be independently designed and combined as desired. The α-helicities of the peptides were photoregulated in on/off or off/on manners, and the manner depended on the positions of two ornithine (Orn) residues for cross-linking reaction at the diarylethene-bridged region. In the case of the on/off manner, when the diarylethene structure adopted the open form on the peptides, the peptides folded into stable α-helices. Upon UV irradiation, the diarylethene moiety isomerized to its closed form to destabilize the helical structures. Quartz crystal microbalance (QCM) analysis showed that the open isomer strongly associated with a target DNA, as compared with the closed one. When the closed-form peptide existing in the DNA complex was irradiated with a fluorescent lamp in the middle of the QCM monitoring, the frequency change (ΔF) was enhanced by the diarylethene photoisomerization. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 32 |
| Volume Number | 18 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2012-08-06 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Cross-Linking Reagents Chemistry DNA Peptides Amino Acid Sequence Binding Sites Circular Dichroism Molecular Structure Photochemistry Protein Conformation Protein Structure, Secondary Spectrophotometry, Ultraviolet Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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