NDLI: Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results

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Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results

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Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Osz, Katalin Rizzarelli, Enrico Kállay, Csilla Impellizzeri, Giuseppe Pappalardo, Giuseppe Di Natale, Giuseppe Sanna, Daniele Sóvágó, Imre
Description	Author Affiliation: Di Natale G ( CNR Institute of Biostructures and Bioimaging, V.le A. Doria 6, 95125 Catania, Italy.)
Abstract	Characterization of the copper(II) complexes formed with the tetraoctarepeat peptide at low and high metal-to-ligand ratios and in a large pH range, would provide a breakthrough in the interpretation of biological relevance of the different metal complexes of copper(II)-tetraoctarepeat system. In the present work, the potentiometric, UV/Vis, circular dichroism (CD), and electron paramagnetic resonance (EPR) studies were carried out on copper(II) complexes with a PEG-ylated derivative of the tetraoctarepeats peptide sequence $(Ac-PEG_{27}-(PHGGGWGQ)_{4}-NH_{2})$ and the peptide $Ac-(PHGGGWGQ)_{2}-NH_{2}.$ Conjugation of tetraoctarepeat peptide sequence with polyethyleneglycol improved the solubility of the copper(II) complexes. The results enable a straightforward explanation of the conflicting results originated from the underestimation of all metal–ligand equilibria and the ensuing speciation. A complete and reliable speciation is therefore obtained with the released affinity and binding details of the main complexes species formed in aqueous solution. The results contribute to clarify the discrepancies of several studies in which the authors ascribe the redox activity of copper(II)-tetraoctarepeat system considering only the average effects of several coexisting species with very different stoichiometries and binding modes.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	11
Volume Number	19
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2013-03-11
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Copper Chemistry Organometallic Compounds Prions Chemical Synthesis Spectrometry, Mass, Electrospray Ionization Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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Copper ii catalyzed C_C and C_O bond formation in organic synthesis and their applications

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Oxidative DNA cleavage promoted by two phenolate-bridged binuclear copper(ii) complexes

Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results

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Affinity, Speciation, and Molecular Features of Copper(II) Complexes with a Prion Tetraoctarepeat Domain in Aqueous Solution: Insights into Old and New Results