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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gam, Jongsik Suh, Young-ger Lee, Seung-goo Moon, Jayoung Lee, Jeeyeon |
| Description | Author Affiliation: Moon J ( College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742 (Korea), Fax: (+82) 2-884-8334.) |
| Abstract | Elucidation of the signal-transmission pathways between distant sites within proteins is of great importance in medical and bioengineering sciences. The use of optical methods to redesign protein functions is emerging as a general approach for the control of biological systems with high spatiotemporal precision. Here we report the detailed thermodynamic and kinetic characterization of novel chimeric light-regulated Tet repressor (TetR) switches in which light modulates the TetR function. Light absorbed by flavin mononucleotide (FMN) generates a signal that is transmitted to As-LOV and YtvA-LOV fused TetR proteins (LOV=light–oxygen–voltage), in which it alters the binding to tetracycline, the TetR ligand. The engineering of light-sensing protein modules with TetR is a valuable tool that deepens our understanding of the mechanism of signal transmission within proteins. In addition, the light-regulated changes of drug binding that we describe here suggest that engineered light-sensitive proteins may be used for the development of novel therapeutic strategies. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 9 |
| Volume Number | 20 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2014-02-24 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Bacillus Subtilis Chemistry Bacterial Proteins DNA-Binding Proteins Protein Structure, Tertiary Drug Effects Tetracycline Pharmacology Amino Acid Sequence Binding Sites Metabolism Fluorescence Models, Molecular Oxygen Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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