NDLI: Self-Assembled Supramolecular Hetero-Bimetallacycles for Anticancer Potency by Intracellular Release

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mishra, Anurag Stang, Peter J. Choi, Eun Ha Cook, Timothy R. Kumar Kaushik, Nagendra Chi, Ki-whan Kaushik, Neha Chang Lee, Seung
Description	Author Affiliation: Mishra A ( Department of Chemistry, University of Ulsan, Ulsan 680-749 (Republic of Korea).)
Abstract	Two new tetracationic hetero-bimetallacycles, compounds 4 and 5, have been constructed from an N,N′-bis(4-(pyridin-4-ylethynyl)phenyl)pyridine-2,6-dicarboxamide ligand (1), and cis-blocked complexes $[M(dppf)(OTf)_{2}]$ (dppf=1,1′-bis(diphenylphosphino)ferrocene; OTf=trifluoromethanesulfonate; M=Pd (2), Pt (3)) in $CH_{3}NO_{2}/CH_{2}Cl_{2}$ (1:1) solvent. Both complexes were isolated with adequate yields as triflate salts and were then characterized using $^{1}H,$ $^{13}C,$ and $^{31}P NMR$ spectroscopy, elemental analysis, UV/Vis spectroscopy, and high-resolution electrospray mass spectrometry (HR-ESMS). The molecular structure of 4 was determined by molecular mechanics force-field calculations. The cytotoxic effect of both new complexes were analyzed against T98G (brain tumor), KB (head and neck cancer), SNU-80 (thyroid cancer), and HEK-293 non-malignant cell lines. The cytotoxicity of complexes 4 and 5 were found to be considerably more effective against cancer cells than reference drug cisplatin. Annexin-V/PI staining, caspase-3/7 activity, and the reduction in mitochondrial membrane potential justify a significant level of apoptosis in complex-treated cells.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	44
Volume Number	20
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2014-10-27
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Antineoplastic Agents Chemistry Pharmacology Coordination Complexes Organoplatinum Compounds Palladium Chemical Synthesis Cell Line, Tumor Drug Screening Assays, Antitumor HEK293 Cells Magnetic Resonance Spectroscopy Neoplasms Drug Therapy Pyridines Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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