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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | She, Shan Zhang, Jin Wei, Yongge Zhang, Jiangwei Bian, Shengtai Hao, Jian |
| Description | Author Affiliation: She S ( Analysis and Test Center, Beijing University of Chemical Technology, Beijing 100029 (P. R. China), Fax: (+86) 10-64412796) |
| Abstract | A series of aliphatic organoimido derivatives of hexamolybdate based on amantadine, namely $(nBu_{4}N)_{2}[Mo_{6}O_{18}(NC_{10}H_{15})]$ (1), $(nBu_{4}N)_{2}$ $\{cis-[Mo_{6}O_{17}(NC_{10}H_{15})_{2}]\}$ (2), $(nBu_{4}N)_{2}\{trans-[Mo_{6}O_{17}(NC_{10}H_{15})_{2}]\}$ (3), and $(nBu_{4}N)_{2}[Mo_{6}O_{16}(NC_{10}H_{15})_{3}]$ (4), was synthesized in reasonable yield by dehydration with N,N′-dicyclohexylcarbodiimide (DCC). They were characterized by IR and UV/Vis spectroscopy, elemental analysis, ESI mass spectrometry, and single-crystal X-ray structure analysis. The spectral and structural similarities and differences between monosubstituted, cis-disubstituted, and trans-disubstituted organoimido derivatives were elucidated and may provide guidance for related work on organoimido-functionalized Lindqvist-type polyoxometalates. In addition, trans-disubstituted and polysubstituted derivatives containing aliphatic organoimido ligands have not yet been reported, and the crystal structure of the trans isomer may lead us to a deeper understanding of disubstituted derivatives. Furthermore, proliferation and morphology of MCF-7 cells were studied with compound 1. The present results show that the DCC-dehydrating protocol could be an efficient approach to covalently graft bioactive ligands such as amantadine onto POMs and enhance their application in clinical cancer treatment. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 51 |
| Volume Number | 20 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2014-12-15 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Amantadine Chemistry Amines Cell Proliferation Drug Effects Imides MCF-7 Cells Molybdenum Organometallic Compounds Tungsten Compounds Crystallography, X-Ray Ligands Magnetic Resonance Spectroscopy Molecular Structure Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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