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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Miao, Jun-ying Zhao, Bao-xiang Zhang, Yan-ru Meng, Ning |
| Description | Author Affiliation: Zhang YR ( Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (P.R. China).); Meng N ( Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100 (P.R. China).); Miao JY ( School of Biological Science and Technology, University of Jinan, Jinan 250022 (P.R. China).); Zhao BX ( Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100 (P.R. China). miaojy@sdu.edu.cn.) |
| Abstract | A simple ratiometric probe (Naph-Rh) has been designed and synthesized based on a through-bond energy transfer (TBET) system for sensing HOCl. In this probe, rhodamine thiohydrazide and naphthalene formyl were connected by simple synthesis methods to construct a structure of monothio-bishydrazide. Free probe Naph-Rh showed only the emission of naphthalene. When probe Naph-Rh reacted with HOCl, monothio-bishydrazide could be converted into 1,2,4-oxadiazole, which not only ensured that the donor and the acceptor were connected with electronically conjugated bonds, but also resulted in the spiro-ring opening and the emission of rhodamine. Therefore, a typical TBET process took place. The probe possessed high-energy transfer efficiency and large pseudo-Stokes shifts. As the first TBET probe for HOCl, Naph-Rh showed excellent selectivity and sensitivity toward HOCl over other reactive oxygen species (ROS)/reactive nitrogen species (RNS), and could respond fast to a low concentration of HOCl in the real sample. In addition, the probe was suitable for imaging HOCl in living cells due to its real-time response, excellent resolution, and reduced cytotoxicity. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 52 |
| Volume Number | 21 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2015-12-21 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Fluorescent Dyes Chemistry Hypochlorous Acid Naphthalenes Oxadiazoles Diagnostic Imaging Fluorescence Resonance Energy Transfer HeLa Cells Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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