NDLI: Rapid Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanorods and Nanotriangles for Colorimetric Single-Nucleotide Discrimination

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Rapid Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanorods and Nanotriangles for Colorimetric Single-Nucleotide Discrimination

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Guoqing Takarada, Tohru Akiyama, Yoshitsugu Maeda, Mizuo
Description	Author Affiliation: Wang G ( Bioengineering Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan), Fax: (+81) 4-8462-4658.); Akiyama Y ( Bioengineering Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan), Fax: (+81) 4-8462-4658.); Takarada T ( Current address: Faculty of Industrial Science and Technology, Tokyo University of Science, 102-1 Tomino, Oshamambe-cho, Yamakoshi-gun, Hokkaido 049-3514 (Japan).); Maeda M ( Bioengineering Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan), Fax: (+81) 4-8462-4658. ttkrd@riken.jp.)
Abstract	Gold nanoparticles modified with DNA duplexes are rapidly and spontaneously aggregated at high ionic strength. In contrast, this aggregation is greatly suppressed when the DNA duplex has a single-base mismatch or a single-nucleotide overhang located at the outermost surface of the particle. These colloidal features emerge irrespective of the size and composition of the particle core; however, the effects of the shape remain unexplored. Using gold nanorods and nanotriangles (nanoplatelets), we show herein that both remarkable rapidity in colloidal aggregation and extreme susceptibility to DNA structural perturbations are preserved, regardless of the shape and aspect ratio of the core. It is also demonstrated that the DNA-modified gold nanorods and nanotriangles are applicable to naked-eye detection of a single-base difference in a gene model. The current study corroborates the generality of the unique colloidal properties of DNA-functionalized nanoparticles, and thus enhances the feasibility of their practical use.
ISSN	09476539
e-ISSN	15213765
Journal	Chemistry - A European Journal
Issue Number	1
Volume Number	22
Language	English
Publisher	Wiley-VCH;ChemPubSoc Europe
Publisher Date	2016-01-04
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	DNA Chemistry Metal Nanoparticles Nanotubes Nucleotides Colorimetry DNA, Single-Stranded Metabolism Particle Size Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Catalysis

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