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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Hong Lin, Bao-ping Geng, Yi Wang, Zhi-fei |
| Description | Author Affiliation: Geng Y ( School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Jiangsu Optoelectronic Functional Materials and Engineering Laboratory, Southeast University, Nanjing, 211189, P.R. China.); Wang ZF ( School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Jiangsu Optoelectronic Functional Materials and Engineering Laboratory, Southeast University, Nanjing, 211189, P.R. China.); Lin BP ( School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Jiangsu Optoelectronic Functional Materials and Engineering Laboratory, Southeast University, Nanjing, 211189, P.R. China.); Yang H ( School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Jiangsu Optoelectronic Functional Materials and Engineering Laboratory, Southeast University, Nanjing, 211189, P.R. China.) |
| Abstract | Encapsulation of inorganic nanoparticles (NPs) in the interfaces of amphiphilic vesicles is a challenging task. The traditional strategy is to use amphiphilic triblock co-polymers, which possess two outer blocks for building the walls and coronas of the vesicles, and one middle NP binding block for localizing NPs at the vesicle interfaces. In this manuscript, we describe the design and synthesis of an amphiphilic diblock co-polymer, that is, PEG-SH-b-PS (PEG=poly(ethylene glycol), PS=polystyrene) bearing a cysteine junction with one free pendant thiol group at the center point between the hydrophilic poly(ethylene glycol) block and the hydrophobic polystyrene block. The amphiphilicity-driven self-assembly in aqueous solution of the pure linear diblock co-polymer PEG-SH-b-PS and the corresponding amphiphilic PEG-SH-b-PS/gold NPs (GNPs) nanocomposites is examined. From TEM observations of the self-assembled samples containing the conjugated GNPs, it can be concluded that most of the GNPs are dispersed at the interfaces of the formed vesicles. In addition, near-infrared (NIR)-absorbing copper monosulfide (CuS) NPs are also encapsulated into the PEG-SH-b-PS vesicles. Due to the photothermal heating effect of the CuS NPs, the corresponding PEG-SH-b-PS/CuSNPs vesicles can disassemble and release the embedded cargos under NIR illumination, which endows this nanocomposite material with potential in biomedical applications, such as cancer imaging, photothermal therapy, and drug delivery. |
| ISSN | 09476539 |
| e-ISSN | 15213765 |
| Journal | Chemistry - A European Journal |
| Issue Number | 50 |
| Volume Number | 22 |
| Language | English |
| Publisher | Wiley-VCH;ChemPubSoc Europe |
| Publisher Date | 2016-12-12 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Catalysis |
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