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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Roberts, J. B. Wilson, A. Thomas, B. H. |
| Abstract | 1. Carbon-14 labelled pyridostigmine in single doses was given by intramuscular injection to pregnant rats, and maternal blood, foetal and placental homogenates were examined for total radioactive content, pyridostigmine and its metabolite, 3-hydroxy-N-methyl pyridinium.2. The level of radioactivity in all tissues was highest at 15 min and fell to negligible amounts at 24 hr. The concentrations in placenta were similar to those in maternal blood, but there was some indication of retention of radioactive drug in the placenta. The concentrations in the foetus were substantially lower, but the subsequent slow decline in concentration suggests that cumulation of the drug could occur with repeated doses.3. The percentage of metabolite in the foetus was considerably higher than in placenta and blood, and the possible reasons for this are discussed. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 38 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1970-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Cholinesterase Inhibitors Metabolism Maternal-Fetal Exchange Pyridinium Compounds Blood Animals Carbon Isotopes Fetus Injections, Intramuscular Placenta Pregnancy Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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