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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sheehan, P. Goldstein, A. Judson, B. A. |
| Abstract | 1. Running activity and brain levorphanol concentration were measured in nontolerant and tolerant mice given various doses of (3)H-levorphanol.2. The principal factor responsible for tolerance in the mouse is a loss of sensitivity to the narcotic drug at the cellular level in brain; despite adequate brain concentrations, the pharmacological effects are diminished or absent.3. There is also metabolic tolerance; a given dose establishes a lower brain concentration in tolerant than in non-tolerant animals.4. The two kinds of tolerance are distinguished here and the contribution of each is assessed. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 47 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1973-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Brain Metabolism Levorphanol Pharmacology Animals Behavior, Animal Drug Effects Brain Chemistry Chromatography, Thin Layer Dose-Response Relationship, Drug Drug Tolerance Injections, Intraperitoneal Administration & Dosage Mice Motor Activity Time Factors Tritium |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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