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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Spiegelstein, M. Y. Grunfeld, Y. |
| Abstract | 1 The effects of Gymnodinium breve neurotoxin (GT) on smooth muscles were studied using the guinea-pig isolated ileum.2 The toxin caused strong spasmogenic effects at 1-4 mug/ml, characterized by prolonged tonic contraction with superimposed pronounced pendular movements. Tachyphylaxis was observed upon administration of successive doses.3 Atropine blocked the contractile response elicited by GT, whereas mepyramine and hexamethonium failed to do so. These findings tentatively suggested a cholinergic involvement at a post-ganglionic site of action.4 In the presence of tetrodotoxin the effects of GT were abolished, excluding direct action of the toxin on the smooth muscle.5 It is concluded that GT exerts its spasmogenic effects through stimulation of the post-ganglionic cholinergic nerve fibres. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 51 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1974-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Dinoflagellida Eukaryota Marine Toxins Pharmacology Muscle Contraction Drug Effects Muscle, Smooth Acetylcholine Animals Atropine Autonomic Fibers, Postganglionic Physiology Benzyl Compounds Drug Interactions Electric Stimulation Ethylenediamines Guinea Pigs Hexamethonium Compounds Histamine H1 Antagonists Ileum In Vitro Techniques Antagonists & Inhibitors Pyridines Tachyphylaxis Tetrodotoxin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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