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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Marshall, K. Senior, J. |
| Description | Author Affiliation: Marshall K ( Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford.) |
| Abstract | 1. The effect of oestradiol on tamoxifen - (single doses of each agent) induced responses in the uterus of the mature ovariectomized rat was investigated. The parameters examined were uterine blood flow (measured by the microsphere technique), weight and oestrogen receptor concentrations. 2. Initially the addition of oestradiol to the tamoxifen regimen produced a reduction in uterine blood flow and dry weight which was reflected by a reduction in nuclear oestrogen receptor. However, as the tamoxifen response became more established from 48 h onwards the addition of oestradiol produced an additive effect. These changes were not mirrored by increases in nuclear oestrogen receptor. 3. The results suggest that tamoxifen and oestradiol may, in part, act via different mechanisms; the role of possible mediatory systems such as histamine release and eosinophil migration is discussed. Heterogeneous control systems may also be involved in the early and late uterine response. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 2 |
| Volume Number | 98 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1989-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Estradiol Pharmacology Hyperemia Chemically Induced Tamoxifen Uterus Blood Supply Animals Cell Nucleus Drug Effects Metabolism Cytoplasm Microspheres Organ Size Rats, Inbred Strains Receptors, Estrogen Regional Blood Flow Uterine Contraction Growth & Development Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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