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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Moreau, J. L. Prud'hon, B. Pieri, L. |
| Description | Author Affiliation: Moreau JL ( Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Basle, Switzerland.) |
| Abstract | 1. Convulsions were induced reproducibly by intracerebroventricular injection of N-methyl-D-aspartic acid (NMDA) to conscious mice. 2. Competitive (carboxypiperazine-propylphosphonic acid, CPP; 2-amino-7-phosphonoheptanoic acid, AP7) and non-competitive (MK801; phencyclidine, PCP; thienylcyclohexylpiperidine, TCP; dextrorphan; dextromethorphan) NMDA antagonists prevented NMDA-induced convulsions. 3. Benzodiazepine receptor agonists and partial agonists (triazolam, diazepam, clonazepam, Ro 16-6028), classical anticonvulsants (diphenylhydantoin, phenobarbitone, sodium valproate) and meprobamate were also found to prevent NMDA-induced convulsions. 4. Flumazenil (a benzodiazepine receptor antagonist) and the GABA agonists THIP and muscimol (up to subtoxic doses) were without effect. 5. Flumazenil reversed the anticonvulsant action of diazepam, but not that of MK801. 6. Results obtained in this model differ somewhat from those described in a seizure model with systemic administration of NMDA. An explanation for this discrepancy is offered. 7. This model is a simple test for assessing the in vivo activity of NMDA antagonists and also expands the battery of chemically-induced seizure models for characterizing anticonvulsants not acting at NMDA receptors. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 3 |
| Volume Number | 98 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1989-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Anti-Anxiety Agents Pharmacology Anticonvulsants Aspartic Acid Analogs & Derivatives Seizures Chemically Induced Animals Administration & Dosage Antagonists & Inhibitors Benzodiazepines Binding, Competitive Drug Effects Injections, Intraventricular Mice N-Methylaspartate Physiopathology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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