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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Scapigliati, G. Becherucci, C. Perretti, M. Parente, L. |
| Description | Author Affiliation: Perretti M ( Sclavo Research Centre, Siena, Italy.) |
| Abstract | 1 Peritoneal macrophages (M phi) collected from adrenalectomized (ADX) rats released more interleukin-1 (IL-1) activity and prostaglandin E2 (PGE2) than macrophages from sham-operated (SHO) rats. 2 The increase in IL-1 activity in the supernatants was confirmed by the increase of the cell-associated 33 kD IL-1 alpha precursor in ADX macrophages stimulated by lipopolysaccharide (LPS). 3 After the injection of Complete Freund's Adjuvant (CFA) to induce adjuvant arthritis, 60% of the ADX rats died, while no deaths occurred in the SHO group. 4 The in vivo administration of dexamethasone inhibited both IL-1 and PGE2 release by macrophages as well as protecting ADX animals from CFA-induced death. Indomethacin and BW 755C partially protected the animals from this lethal effect. 5 These results suggest that adrenalectomy induces an increased release of IL-1 both in vitro and in vivo, and are consistent with a feedback mechanism between IL-1 and glucocorticoid hormones. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 98 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1989-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Adrenalectomy Interleukin-1 Metabolism 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine Pharmacology Animals Cells, Cultured Dexamethasone Dinoprostone Freund's Adjuvant In Vitro Techniques Indomethacin Lipopolysaccharides Macrophages Drug Effects Precipitin Tests Rats, Inbred Strains |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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