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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Küpfer, A. Zysset, T. Pessayre, D. Honegger, U. Müller, O. Tinel, M. Pirovino, M. |
| Description | Author Affiliation: Pirovino M ( Medizinische Klinik, Universität Bern, Switzerland.) |
| Abstract | 1. It has previously been shown that the extent of hepatic phospholipidosis induced by chronic amiodarone treatment correlates with the degree of drug accumulation in liver tissue. 2. To investigate a possible influence of pharmacogenetic factors, biochemical and morphological investigations were carried out in two rat strains differing in debrisoquine hydroxylation. 3. Plasma and liver tissue concentrations of amiodarone and its main metabolite, desethyl-amiodarone, were significantly higher in rats with deficient hydroxylation. Microsomal enzyme induction, drug cytochrome P-450 complex formation and typical ultrastructural features of phospholipidosis were only seen in rats with deficient hydroxylation and in a more sensitive species, the guinea-pig. 4. It remains to be seen whether deficient debrisoquine hydroxylation in man is associated with an increased susceptibility to amiodarone side effects. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 99 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1990-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Amiodarone Pharmacology Liver Metabolism Pharmaceutical Preparations Analogs & Derivatives Blood Animals Body Weight Drug Effects Chromatography, Gas Chromatography, High Pressure Liquid Enzyme Induction Hydroxylation Enzymology Microscopy, Electron Microsomes, Liver Organ Size Phenotype Phospholipids Rats, Inbred Strains Species Specificity Comparative Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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